ArticleOpen forum infectious diseases2026
Genomic Surveillance Uncovers a Shift in Respiratory Syncytial Virus Subtype Dominance and the Local Expansion of Subclade B.D.E.1.7.
Article in Open forum infectious diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Respiratory syncytial virus (RSV) is a leading cause of hospitalization among children under 5 and adults over 60 due to its ability to cause acute respiratory illness. Recent approvals of vaccines and monoclonal antibodies against RSV have raised concerns about the potential of prophylactic-evading viral mutations. Method: We analyzed 126 RSV-positive nasopharyngeal swabs from Boston Medical Center during the 2024-2025 respiratory season via amplicon-based whole-genome sequencing. We identified nucleotide variants, assigned clades, and built maximum-likelihood phylogenetic trees to examine genetic changes and evolution. Results: Out of the 126 genomes analyzed, 94 (74.6%) were RSV-A subtype, indicating a return to RSV-A dominance in the region. Within the RSV-B genomes, a large minority belong to the recently defined B.D.E.1.7 subclade (n = 12, 37.5% of RSV-B samples), which has only appeared sporadically in other US states. Mutations associated with monoclonal antibody or vaccine resistance were not observed. Conclusions: These findings show that in the Boston metropolitan area, RSV subtype dominance continues to flip between seasons. Investigation of the clades within both subtypes did not reveal evidence of any virus seeding from the preceding season. Though no mutations associated with prophylactic resistance were identified, surveillance of RSV remains critical to study evolution and transmission dynamics, particularly at the local level.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.