Evidence map›Paper›PMID 42751449›Full record

ArticleRSC advances2026

Dual inhibitors of CDK2 and TRKA kinases: design, synthesis, antiproliferative activity and molecular modeling of novel pyrazolopyrimidine derivatives.

Mohamed H Attia, Deena S Lasheen, Nermin Samir, Azza T Taher, Hatem A Abdel-Aziz, Dalal A Abou El Ella

Abstract read
In one paragraph

Article in RSC advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Mohamed H AttiaDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, October 6 University 6 of October City Giza Egypt mohammed_attia@o6u.edu.eg.ORCID https://orcid.org/0009-0000-0888-1605
Deena S LasheenPharmaceutical Chemistry Department, Faculty of Pharmacy, Ain Shams University Abbassia 11566 Cairo Egypt dalal@pharma.asu.edu.eg.ORCID https://orcid.org/0000-0001-7698-9757
Nermin SamirPharmaceutical Chemistry Department, Faculty of Pharmacy, Ain Shams University Abbassia 11566 Cairo Egypt dalal@pharma.asu.edu.eg.
Azza T TaherDepartment of Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Cairo University Cairo Egypt.
Hatem A Abdel-AzizDepartment of Applied Organic Chemistry, National Research Center Dokki Cairo 12622 Egypt.
Dalal A Abou El EllaPharmaceutical Chemistry Department, Faculty of Pharmacy, Ain Shams University Abbassia 11566 Cairo Egypt dalal@pharma.asu.edu.eg.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Simultaneous inhibition of CDK2 and TRKA presents a promising therapeutic avenue for cancer treatment, capitalizing on the critical roles of CDK2 in cell cycle regulation and TRKA in tumor cell survival and progression. In continuation of our previous work on dual CDK2/TRKA inhibitors, two series of pyrazolo[1,5-

Identifiers

PMID42751449
PMCPMC13579623

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.