Evidence map›Paper›PMID 42753002›Full record

ReviewJournal of immunology research2026

Cancer-Testis Antigens in Immuno Oncology Mechanisms Therapeutic Strategies and Clinical Perspectives.

Ranran Shi, Ling Ran, Tiantian Song, Xiaowen Zhou, Wenshan Zhao, Yijie Zhang

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of immunology research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ranran ShiDepartment of Basic Medical Sciences, Luohe Medical College, Luohe 462000, China, lhmc.edu.cn.ORCID https://orcid.org/0000-0003-0178-7581
Ling RanDepartment of Basic Medical Sciences, Luohe Medical College, Luohe 462000, China, lhmc.edu.cn.
Tiantian SongDepartment of Basic Medical Sciences, Luohe Medical College, Luohe 462000, China, lhmc.edu.cn.
Xiaowen ZhouSchool of Life Sciences, Zhengzhou University, Zhengzhou 450001, China, zzu.edu.cn.
Wenshan ZhaoSchool of Life Sciences, Zhengzhou University, Zhengzhou 450001, China, zzu.edu.cn.ORCID https://orcid.org/0000-0002-8018-5978
Yijie ZhangDepartment of Basic Medical Sciences, Luohe Medical College, Luohe 462000, China, lhmc.edu.cn.

Funding

Doctoral Scientific Research Start-up Foundation of Luohe Medical College 2022-DF-02Key Research Projects of Higher Education Institutions in Henan Province 24B310002Key Research Projects of Higher Education Institutions in Henan Province 25A180007Luohe Medical College Science and Technology Innovation Project 2023ZD01Luohe Medical College Science and Technology Innovation Project KJCX202401National Natural Science Foundation of China 82404497Natural Science Foundation of Henan Province 252300420627Science and Technology Research Project of Henan Provincial Department of Science and Technology 252102310393
6 · The paper itself

Abstract

Cancer-testis antigens (CTAs) represent a unique class of tumor-associated antigens (TAAs) with highly restricted expression in immune-privileged tissues and widespread aberrant activation in various malignancies. Their potent immunogenicity and tumor specificity make CTAs promising targets for cancer immunotherapy. This review provides a comprehensive overview of the molecular regulation, biological functions, and therapeutic applications of CTAs. We detail the genetic and epigenetic mechanisms that drive CTA expression in cancer, their roles in tumor progression, and their capacity to elicit robust CD8

Indexed as

Antigens, NeoplasmImmunotherapyNeoplasmsTestisAnimalsCancer VaccinesEpigenesis, GeneticHumansImmune Checkpoint InhibitorsMaleAntigens, NeoplasmCancer VaccinesImmune Checkpoint Inhibitorsantigen-specific vaccinescancer-testis antigens (CTAs)immune checkpoint inhibitorstumor heterogeneitytumor immunotherapy

Identifiers

PMID42753002
PMCPMC13584331

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.