Evidence map›Paper›PMID 42754707›Full record

ReviewNature microbiology2026

Bacterial growth rate in populations and single cells.

Petra Anne Levin, Jue D Wang

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Petra Anne LevinDepartment of Biology, Washington University in St. Louis, St. Louis, MO, USA. plevin@wustl.edu.ORCID http://orcid.org/0000-0003-2071-0547
Jue D WangDepartment of Bacteriology, University of Wisconsin-Madison, Madison, WI, USA. wang@bact.wisc.edu.ORCID http://orcid.org/0000-0003-1503-170X

Funding

U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS) NIH R35GM127088U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS) NIH R35GM127331
6 · The paper itself

Abstract

Bacterial growth is straightforward to measure, complex in origin and exquisitely sensitive to environmental and genetic perturbations. As a quantifiable parameter, growth rate is central to modern microbiology, conflictingly portrayed as both an output and an input of physiological state. Here we provide a short history of bacterial growth measurement and explain the centrality of growth rate to modern microbiology. We then examine the physical and regulatory connections between nutrient availability, macromolecular synthesis and growth rate. We focus particular attention on (p)ppGpp, a nucleotide alarmone that offers the best-characterized mechanism for coordinating environmental conditions with growth. We end by addressing the cell-autonomous nature of homeostatic control as the basis of growth rate heterogeneity, discussing why the individual cell is paramount when it comes to understanding the relationship between different aspects of physiology, including macromolecular composition, cell size, cell cycle progression and growth rate.

Identifiers

PMID42754707

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.