ArticleBrain and behavior2026
The Role of Self-Compassion on Self-Care With the Mediating Role of Illness Perception in Patients With Multiple Sclerosis Referred to Sina Hospital: Based on the Leventhal Model.
Article in Brain and behavior, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundMultiple sclerosis (MS) is a chronic neurodegenerative disorder associated with diverse physical and psychological challenges. Effective self-care behaviors are essential for managing symptoms and improving quality of life. Psychological constructs such as self-compassion and illness perception are key determinants of self-management in chronic illness.
objectiveThis study investigated the role of self-compassion in promoting self-care behaviors among patients with MS, emphasizing the mediating role of illness perception based on Leventhal's Common-Sense Model.
methodsA cross-sectional analytical study was conducted among 360 patients with MS referred to Sina Hospital, Tehran. Participants completed the Self-Care of Chronic Illness Inventory (Version 4.c), Revised Illness Perception Questionnaire (IPQ-R), and Self-Compassion Scale (SCS). Structural equation modeling (SEM) was used to examine direct and indirect relationships between self-compassion, illness perception dimensions, and self-care behaviors. Model fit was evaluated using χ
resultsSelf-compassion had a significant positive direct effect on self-care (β = 0.30, p = 0.006). Indirect effects were also found through personal control (β = 0.15, p = 0.004), emotional representation (β = 0.22, p = 0.011), and illness coherence (β = 0.15, p = 0.030). Other illness perception dimensions, including treatment control and timeline beliefs, did not show significant mediation effects (p > 0.05).
conclusionSelf-compassion promotes self-care behaviors in MS patients both directly and indirectly by enhancing adaptive illness perceptions-particularly personal control, illness coherence, and emotional balance. Interventions aimed at fostering self-compassion and reframing maladaptive illness perceptions may strengthen disease self-management and psychological well-being.
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