ArticleFrontiers in immunology2026
Dysbiosis of nasal microbiota associated with hippocampal neuroimmune alterations in a mouse model of eosinophilic chronic rhinosinusitis.
Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chronic rhinosinusitis (CRS) is a chronic inflammatory disease of the nasal cavity and paranasal sinuses. Eosinophilic CRS (ECRS) is a refractory subtype characterized by persistent type 2 inflammation. Epidemiological and animal studies suggest that CRS may affect brain function and that microbiota dysbiosis may contribute to the pathophysiology of CRS. However, the relationship between microbiota alterations and neuroimmune changes remains poorly understood in CRS. In this study, we investigated nasal and gut microbiota together with glial and inflammatory gene expression in the olfactory bulb (OB) and hippocampus in a mouse model of ECRS, and examined their associations. The nasal and cecal microbiota were analyzed by 16S rRNA gene amplicon sequencing, and glial and inflammatory gene expression in the OB and hippocampus was assessed by real-time RT-PCR. Associations between microbial taxa and brain gene expression were analyzed using MaAsLin2. While alpha diversity was unchanged, beta diversity of both nasal and gut microbiota differed significantly in ECRS mice. Differential abundance analyses identified several nasal and gut bacterial taxa altered in ECRS. In parallel, expression of glial markers was increased in the OB and hippocampus, and expression of the pro-inflammatory cytokine gene
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.