Evidence map›Paper›PMID 42755732›Full record

ArticleFrontiers in medicine2026

The FT4/FT3 ratio combined with thyroglobulin and parathyroid hormone for distinguishing benign from malignant thyroid nodules: a retrospective study based on histopathological diagnosis.

Zhulin Zhang, Yun Lan

Abstract read
In one paragraph

Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Zhulin ZhangDepartment of Clinical Laboratory, School of Medicine, Nanjing Tongren Hospital, Southeast University, Nanjing, Jiangsu, China.
Yun LanDepartment of Clinical Laboratory, School of Medicine, Nanjing Tongren Hospital, Southeast University, Nanjing, Jiangsu, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: To evaluate the diagnostic value of the FT4/FT3 ratio combined with other laboratory markers in distinguishing malignant from benign thyroid nodules. Methods: This retrospective study analyzed 359 patients with thyroid nodules (142 benign, 217 malignant) based on histopathological results. Clinical and laboratory data, including FT3, FT4, FT4/FT3 ratio, thyroglobulin (TG), parathyroid hormone (PTH), and TSH, were collected. Statistical analyses included ROC curves and multivariate logistic regression. Results: Malignant nodules showed higher FT4/FT3 ratios, TG, PTH, and TSH levels ( Conclusion: The FT4/FT3 ratio, combined with TG and PTH levels, enhances the differentiation of malignant thyroid nodules, offering a reliable diagnostic tool.

Indexed as

FT4/FT3 ratiomalignant thyroid tumormultivariate logistic regressionparathyroid hormoneROC analysisthyroglobulinthyroid nodules

Identifiers

PMID42755732
PMCPMC13581804

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.