Evidence map›Paper›PMID 42755740›Full record

ArticleFrontiers in immunology2026

Letermovir for cytomegalovirus prophylaxis after allogeneic hematopoietic stem cell transplantation in acute leukemia patients: results of the LETreal study.

Yi Xia, Qi Wen, Jing Liu, Jinfang Zhao, Xiaohui Zhang, Lanping Xu, Yu Wang, Yuhong Chen, Yuanyuan Zhang, Yuqian Sun and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Yi Xia *Peking University People's Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Cell and Gene Therapy for Hematologic Malignancies, Peking University, Beijing, China.
Qi Wen *Peking University People's Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Cell and Gene Therapy for Hematologic Malignancies, Peking University, Beijing, China.
Jing Liu *Peking University People's Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Cell and Gene Therapy for Hematologic Malignancies, Peking University, Beijing, China.
Jinfang Zhao *Peking University People's Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Cell and Gene Therapy for Hematologic Malignancies, Peking University, Beijing, China.
Xiaohui ZhangPeking University People's Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Cell and Gene Therapy for Hematologic Malignancies, Peking University, Beijing, China.
Lanping XuPeking University People's Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Cell and Gene Therapy for Hematologic Malignancies, Peking University, Beijing, China.
Yu WangPeking University People's Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Cell and Gene Therapy for Hematologic Malignancies, Peking University, Beijing, China.
Yuhong ChenPeking University People's Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Cell and Gene Therapy for Hematologic Malignancies, Peking University, Beijing, China.
Yuanyuan ZhangPeking University People's Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Cell and Gene Therapy for Hematologic Malignancies, Peking University, Beijing, China.
Yuqian SunPeking University People's Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Cell and Gene Therapy for Hematologic Malignancies, Peking University, Beijing, China.
Yifei ChengPeking University People's Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Cell and Gene Therapy for Hematologic Malignancies, Peking University, Beijing, China.
Yao ChenPeking University People's Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Cell and Gene Therapy for Hematologic Malignancies, Peking University, Beijing, China.
Wei HanPeking University People's Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Cell and Gene Therapy for Hematologic Malignancies, Peking University, Beijing, China.
Fengrong WangPeking University People's Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Cell and Gene Therapy for Hematologic Malignancies, Peking University, Beijing, China.
Jingzhi WangPeking University People's Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Cell and Gene Therapy for Hematologic Malignancies, Peking University, Beijing, China.
Jun KongPeking University People's Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Cell and Gene Therapy for Hematologic Malignancies, Peking University, Beijing, China.
Leqing CaoPeking University People's Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Cell and Gene Therapy for Hematologic Malignancies, Peking University, Beijing, China.
Daoxing DengPeking University People's Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Cell and Gene Therapy for Hematologic Malignancies, Peking University, Beijing, China.
Xiaojun HuangPeking University People's Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Cell and Gene Therapy for Hematologic Malignancies, Peking University, Beijing, China.
Xiaodong MoPeking University People's Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Cell and Gene Therapy for Hematologic Malignancies, Peking University, Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: Cytomegalovirus (CMV) infection can cause severe morbidity and mortality in patients undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT). Letermovir is recommended as CMV prophylaxis for allo-HSCT recipients. This study aimed to further confirm the efficacy of letermovir prophylaxis in different subgroups based on a large cohort of acute leukemia patients following allo-HSCT. Methods: 1331 acute leukemia patients who underwent allo-HSCT (including 978 and 353 patients with and without letermovir prophylaxis, respectively) were enrolled. The occurrence of clinically significant CMV infection (cs-CMVi), CMV disease, and refractory CMV infection were evaluated. Propensity score matching (PSM) was applied to balance baseline characteristics between patients with and without letermovir. Results: In patients receiving letermovir, the 100-day cumulative incidence of cs-CMVi after allo-HSCT was 7.1% (95% CI, 5.5-8.7%), and this rate was greater in children; however, no variables increased the risk of cs-CMVi at 100 days according to multivariate analysis. The cumulative incidence rates of cs-CMVi and CMV disease between 100 and 200 days after allo-HSCT for patients receiving letermovir prophylaxis were 12.5% (95% CI, 10.3-14.7%) and 1.6% (95% CI, 0.8-2.4%), respectively. For the subgroup of patients who did not experience a CMV infection within the first 100 days, these rates were 11.7% (95% CI, 9.5-13.9%) and 1.4% (95% CI, 0.6-2.2%), respectively. Donor-/recipient+ CMV serostatus (44.2%, HR, 5.00; P<0.001) independently increased the risk of cs-CMVi, and age > 60 years (5.0%, HR, 4.01; P = 0.030) increased the risk of CMV disease between 100 and 200 days after allo-HSCT. After PSM adjustment, letermovir prophylaxis was associated with a lower incidence of cs-CMV infection (grade II-IV: 1.9% vs. 10.7%, P = 0.024; grade III-IV: 0% vs. 27.3%, P<0.001) in patients with acute graft-versus-host disease (GVHD). The incidence of cs-CMVi was 18.4% (95% CI, 7.4-29.4%) among chronic GVHD patients receiving letermovir prophylaxis. The incidence of cs-CMVi between 100 and 200 days after allo-HSCT was comparable between patients with prolonged letermovir prophylaxis and those without letermovir prophylaxis. Conclusion: We confirmed the efficacy of letermovir prophylaxis in different subgroups, but the subgroup who would benefit most from prolonged prophylaxis should be further clarified in the future.

Indexed as

AcetatesAntiviral AgentsCytomegalovirusCytomegalovirus InfectionsHematopoietic Stem Cell TransplantationQuinazolinesAdolescentAdultChildChild, PreschoolFemaleHumansIncidenceInfantMaleMiddle AgedAcetatesAntiviral AgentsletermovirQuinazolinesacute leukemiaallogeneic hematopoietic stem cell transplantationcytomegalovirusletermovirprophylaxis

Identifiers

PMID42755740
PMCPMC13581788

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.