Evidence map›Paper›PMID 42755852›Full record

ArticleFrontiers in immunology2026

INPP5K limits PtdIns (4,5)P2 accumulation in CD19 microclusters and restrains CD19 co-receptor membrane proximity and BCR-proximal signaling in B cells.

Bastien Moës, Alice Mostafa, Romain Malempré, Olivier Renson, Géraldine Piel, André Matagne, Stéphane Schurmans, Alice Mayer

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In one paragraph

Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Bastien MoësLaboratory of Functional Genetics, GIGA Research Centre, University of Liège, Avenue de l'Hôpital, Liège, Belgium.
Alice MostafaLaboratory of Functional Genetics, GIGA Research Centre, University of Liège, Avenue de l'Hôpital, Liège, Belgium.
Romain MalempréLaboratory of Enzymology and Protein Folding, Centre for Protein Engineering, InBioS Research Unit, University of Liège, Allée du Août, Liège, Belgium.
Olivier RensonGIGA Bioinformatics, GIGA Research Centre, University of Liège, Avenue de l'Hôpital, Liège, Belgium.
Géraldine PielLaboratory of Pharmaceutical Technology and Biopharmacy, Center for Interdisciplinary Research on Medicines, University of Liège, Avenue Hippocrate, Liege, Belgium.
André MatagneLaboratory of Enzymology and Protein Folding, Centre for Protein Engineering, InBioS Research Unit, University of Liège, Allée du Août, Liège, Belgium.
Stéphane Schurmans *Laboratory of Functional Genetics, GIGA Research Centre, University of Liège, Avenue de l'Hôpital, Liège, Belgium.
Alice Mayer *GIGA Bioinformatics, GIGA Research Centre, University of Liège, Avenue de l'Hôpital, Liège, Belgium.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: CD19 is a key B-cell co-receptor that amplifies B-cell receptor (BCR) signaling and tunes B-cell activation thresholds. How the conformation of the CD19 cytoplasmic domain is regulated to restrain basal and BCR-induced signaling remains incompletely understood. We investigated whether the phosphoinositide 5-phosphatase INPP5K controls CD19 conformation and CD19-amplified BCR-proximal signaling through local regulation of phosphatidylinositol 4,5-bisphosphate [PtdIns(4,5)P Methods: A B-cell-specific Results: The CD19 juxtamembrane cytoplasmic domain contains a conserved polybasic region that interacts with acidic phospholipids, including PtdIns(4,5)P Discussion: INPP5K limits local PtdIns(4,5)P

Indexed as

Antigens, CD19B-LymphocytesPhosphatidylinositol 4,5-DiphosphateReceptors, Antigen, B-CellSignal TransductionAnimalsCell MembraneLymphocyte ActivationMicePhosphoinositide 5-PhosphatasesAntigens, CD19CD19 antigen, mousePhosphatidylinositol 4,5-DiphosphatePhosphoinositide 5-PhosphatasesReceptors, Antigen, B-CellB cellsCD19 siganling moleculeimmunologymolecular Biologyphosphoinositides

Identifiers

PMID42755852
PMCPMC13581894

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.