Evidence map›Paper›PMID 42756270›Full record

ArticleFrontiers in pharmacology2026

1,8-Cineole improves hepatic fibrosis by inhibiting HIF-1α/BNIP3/PINK1/Parkin-dependent mitophagy signaling and inducing apoptosis in activated hepatic stellate cells.

Lifeng Qin, Jiawu Tan, Chan He, Maoyin He, Jiqiao Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Lifeng QinHubei Provincial Key Laboratory of Occurrence and Intervention of Rheumatic Diseases, Minda Hospital of Hubei Minzu University, Enshi, Hubei, China.
Jiawu TanDepartment of Gastroenterology, Minda Hospital of Hubei Minzu University, Enshi, Hubei, China.
Chan HeDepartment of Gastroenterology, Minda Hospital of Hubei Minzu University, Enshi, Hubei, China.
Maoyin HeDepartment of Gastroenterology, Minda Hospital of Hubei Minzu University, Enshi, Hubei, China.
Jiqiao ZhangDepartment of Gastroenterology, Minda Hospital of Hubei Minzu University, Enshi, Hubei, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aim: The HIF-1α/BNIP3/mitophagy signaling pathway might be closely associated with hepatic fibrosis. Although 1,8-cineole (CIN) has been shown to improve fibrosis in several organs, direct evidence for its anti-hepatic fibrotic effects remains lacking. The objective of this study was to confirm the role of mitophagy in hepatic stellate cells (HSCs) and the role of the HIF-1α/BNIP3 signaling pathway in the pathogenesis of hepatic fibrosis. Additionally, Methods: In a CCl Results: Our findings indicated that CIN significantly mitigated CCl Conclusion: CIN improves hepatic fibrosis by inhibiting HIF-1α/BNIP3/PINK1/Parkin-dependent mitophagy signaling and inducing apoptosis in activated HSCs.

Indexed as

1,8-cineolehepatic fibrosisHIF-1α/BNIP3mitophagyPink1/Parkin

Identifiers

PMID42756270
PMCPMC13583035

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.