ReviewFrontiers in chemistry2026
Antitumor and proliferative modulation by N- and O-heterocycles: a comprehensive review of cell growth regulation.
Review in Frontiers in chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The persistence of resistance, recurrence, and limited selectivity in cancer therapy necessitates the development of structurally advanced antitumor agents capable of modulating multiple intracellular pathways. This review provides a systematic analysis of nitrogen- and oxygen-containing heterocycles as key platforms in anticancer drug design, with an emphasis on integrated molecular architectures combining multiple pharmacophoric fragments. A central and unifying principle emerging from the analyzed studies is the decisive role of hydrazide-hydrazone functionalization as a pharmacophoric enhancer, which should be considered not merely as a substituent but as a core structural element governing conformational flexibility, electronic distribution, and target-binding efficiency. Its incorporation consistently correlates with enhanced antiproliferative activity, apoptosis induction, and improved selectivity across diverse tumor models. Within this framework, the most efficient representatives highlight the practical significance of this design strategy: compound 17 demonstrates exceptional activity with GI
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.