ReviewThe Biochemical journal2026
Design rules for bioorthogonal glycan-based tools.
Review in The Biochemical journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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4 authors.
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Abstract
As one of the most abundant and diverse post-translational modifications in biology, glycosylation has a significant influence on the functions of proteins in health and disease. To untangle the complexity of glycan biosynthetic pathways, the process of studying glycosylation has been expedited by specialised, chemical labelling techniques. In the present review, we explore the development of metabolic glycan labelling from early biochemical methods to current approaches that use interdisciplinary techniques. We highlight work that has informed our understanding of glycan biosynthesis through pioneering chemical biology approaches. Moreover, we provide guidance for experimental design that can be tailored to the specific needs of those investigating glycosylation in the context of their own work. Our 'Design Rules' consolidate the findings of several groups in a simple roadmap to make metabolic glycan labelling as effective as possible.
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