ArticleThe Plant cell2026
RNA m6A methylation fine-tunes the jasmonic acid biosynthesis pathway to modulate plant aging.
Article in The Plant cell, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
N 6-Methyladenosine (m6A) is a context-dependent mRNA modification, yet how its dynamics integrate with endogenous signaling to shape plant development remains unclear. Here, we provide further evidence for HIZ2 as an essential component of the m6A writer complex in Arabidopsis, which methylates and destabilizes mRNAs decoding multiple enzymes acting in sequential steps of jasmonic acid biosynthesis, thereby ensuring jasmonic acid homeostasis required for timely leaf senescence. HIZ2 interacts with and is indispensable for maintaining the abundance of key m6A writer complex components, including MTA. HIZ2 is required for transcriptome-wide m6A deposition, notably on transcripts of multiple jasmonic acid biosynthesis genes, which are subsequently recognized and destabilized by the m6A readers ECT2/3/4. During aging, reduced m6A deposition on these transcripts permits their accumulation, thus elevating jasmonic acid levels that drive the progression of leaf senescence. Our findings indicate that coordinated m6A-dependent regulation of multiple jasmonic acid biosynthesis transcripts fine-tunes jasmonic acid homeostasis and contributes to the timely progression of leaf senescence.
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