Evidence map›Paper›PMID 42758809›Full record

ArticleScience advances2026

Multiomics profiling identifies molecular and cellular signatures of regular exercise in human peripheral blood.

Xuemei Song, Jingzhi Lv, Siliang Ge, Sihan Xu, Yisha Wu, Yuhui Zheng, Wenwen Zhou, Lifeng Li, Yan Zhang, Jiaqiang Zhang and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Xuemei SongState Key Laboratory of Genome and Multi-omics Technologies, BGI Research, Shenzhen 518083, China.ORCID 0009-0001-5293-6324
Jingzhi LvState Key Laboratory of Molecular Oncology, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Peking University Cancer Hospital & Institute, Beijing 100021, China.ORCID 0009-0008-7956-4437
Siliang GeDepartment of Orthopedics, Chinese PLA General Hospital, Beijing 100853, China.ORCID 0009-0008-7498-8089
Sihan XuHenan Institute of Medical and Pharmaceutical Sciences & BGI College, Zhengzhou University, Zhengzhou 450052, China.ORCID 0009-0006-7551-0154
Yisha WuState Key Laboratory of Genome and Multi-omics Technologies, BGI Research, Shenzhen 518083, China.ORCID 0000-0002-9751-2461
Yuhui ZhengState Key Laboratory of Genome and Multi-omics Technologies, BGI Research, Shenzhen 518083, China.ORCID 0000-0001-5760-0048
Wenwen ZhouState Key Laboratory of Genome and Multi-omics Technologies, BGI Research, Shenzhen 518083, China.ORCID 0009-0009-1130-4951
Lifeng LiBGl Sports Genomics Institute, Shenzhen 518083, China.
Yan ZhangState Key Laboratory of Genome and Multi-omics Technologies, BGI Research, Shenzhen 518083, China.ORCID 0000-0003-2281-7807
Jiaqiang ZhangDepartment of Anesthesiology and Perioperative Medicine, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, People's Hospital of Henan Academy of Innovations in Medical Science, Zhengzhou 450003, China.ORCID 0000-0002-1367-9644
Zhen-Xia ChenCollege of Life Sciences and Technology, Huazhong Agricultural University, Wuhan 430070, China.ORCID 0000-0003-0474-902X
Peng GaoShanxi Medical University-BGI Collaborative Center for Future Medicine, Shanxi Medical University, Taiyuan 030001, China.ORCID 0000-0002-5969-118X
Pengbin YinDepartment of Orthopedics, Chinese PLA General Hospital, Beijing 100853, China.ORCID 0000-0002-5391-4477
Jianhua YinShanxi Medical University-BGI Collaborative Center for Future Medicine, Shanxi Medical University, Taiyuan 030001, China.ORCID 0000-0003-1207-7788
Chuanyu LiuShanxi Medical University-BGI Collaborative Center for Future Medicine, Shanxi Medical University, Taiyuan 030001, China.ORCID 0000-0003-2258-0897

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Regular exercise is well established to protect against metabolic disorders and bolster immunity, but the underlying molecular and cellular mechanisms remain incompletely understood. We integrated plasma metabolomics and lipidomics with single-cell transcriptomic and chromatin accessibility profiles from regularly exercising versus sedentary individuals. We observed that regular exercise was associated with enhanced fatty acid oxidation and antioxidant metabolites in plasma. In the circulating immune cells of exercising individuals, antigen-presenting cells (APCs), particularly classical monocytes and B cells, showed concordant increases in both chromatin accessibility and transcription of antigen presentation genes. CD8

Indexed as

ExerciseAntigen-Presenting CellsFatty AcidsGene Expression ProfilingHumansLipidomicsMetabolomeMetabolomicsMultiomicsTranscriptomeFatty Acids

Identifiers

PMID42758809
PMCPMC13588174

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.