Evidence map›Paper›PMID 42758834›Full record

ArticleScience advances2026

Thalamic modulation of cortical linearity across arousal states.

Eli J Müller, Brandon R Munn, Giulia Baracchini, Ben D Fulcher, Vicente Medel, Michelle J Redinbaugh, Yuri B Saalmann, Jordan J Wehrman, Robert D Sanders, Bingni W Brunton and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Eli J MüllerSchool of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia.ORCID 0000-0003-2497-0194
Brandon R MunnSchool of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia.ORCID 0000-0002-3638-1605
Giulia BaracchiniSchool of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia.ORCID 0000-0001-9198-2780
Ben D FulcherSchool of Physics, The University of Sydney, Sydney, NSW, Australia.ORCID 0000-0002-3003-4055
Vicente MedelLatin American Brain Health Institute, Universidad Adolfo Ibañez, Santiago, Chile.ORCID 0000-0003-2443-8683
Michelle J RedinbaughDepartment of Biology, Stanford University, Stanford, CA, USA.ORCID 0000-0003-1367-8606
Yuri B SaalmannDepartment of Psychology, University of Wisconsin-Madison, Madison, WI, USA.ORCID 0000-0001-8880-6698
Jordan J WehrmanCentral Clinical School, Faculty of Medicine and Health, The University of Sydney, NSW, Australia.ORCID 0000-0002-9358-6092
Robert D SandersCentral Clinical School, Faculty of Medicine and Health, The University of Sydney, NSW, Australia.
Bingni W BruntonDepartment of Biology, University of Washington, Seattle, WA, USA.ORCID 0000-0002-4831-3466
Steven L BruntonDepartment of Mechanical Engineering, University of Washington, Seattle, WA, USA.ORCID 0000-0002-6565-5118
James M ShineSchool of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia.ORCID 0000-0003-1762-5499

Funding

WNPRC Supplemental Request for Nonhuman Primate Enclosures to Equip HIV/AIDS-Related Research FacilitiesP51OD011106 · OD · UNIVERSITY OF WISCONSIN-MADISON · PI Dorota A. Grejner-Brzezinska · 2012 to 2026
$150.7M
Prefrontal cortico-thalamic dynamics in cognitive controlR01MH110311 · NIMH · UNIVERSITY OF WISCONSIN-MADISON · PI SAALMANN, YURI B · 2016 to 2020
$1.8M
NIH HHS P51 OD011106NIMH NIH HHS R01 MH110311
6 · The paper itself

Abstract

The human brain must support both stable and flexible neural dynamics to adapt to changing contexts. The thalamus has been hypothesized to coordinate these opposing dynamical regimes in the cerebral cortex; however, this has not been directly tested at the systems level. Here, we apply a time-resolved measure of linearity to multimodal recordings in humans and macaques, demonstrating irregular fluctuations in both human functional magnetic resonance imaging and electrophysiological in the awake state. These fluctuations follow a key neuroanatomical axis of the thalamus, are diminished under pharmacological ablation of arousal, and recovered following arousal-inducing direct electrical stimulation of thalamus. Together, these findings identify a thalamic organizational axis that modulates cortical linearity across arousal states, linking thalamocortical architecture to the regulation of large-scale cortical dynamics.

Indexed as

ArousalCerebral CortexThalamusAnimalsBrain MappingHumansMagnetic Resonance ImagingMale

Identifiers

PMID42758834
PMCPMC13588182

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.