Evidence map›Paper›PMID 42760967›Full record

Observational studyFrontiers in endocrinology2026

Plasma cortisol cut-off concentrations using the dexamethasone suppression test in patients with adrenal incidentalomas.

Nanna Thurmann Jørgensen, Stina Willemoes Borresen, Linda Hilsted, Christina Christoffersen, Kasper Brødbæk, Randi Ugleholdt, Claus Larsen Feltoft, Line Koch Skaanning, Per Medbøe Thorsby, Åse Krogh Rasmussen and 2 more

Registry-linked trialAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Frontiers in endocrinology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07350031 (Cortisol Assessment in Patients With Adrenal Incidentalomas), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07350031 completednot on this map

Cortisol Assessment in Patients With Adrenal Incidentalomas

TypeobservationalSponsorRigshospitalet, DenmarkRan2016 to 2024Enrolled209ConditionsAdrenal Incidentaloma, HypercortisolismArms1 mg overnight dexamethasone suppression test
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Nanna Thurmann JørgensenDepartment of Nephrology and Endocrinology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
Stina Willemoes BorresenDepartment of Nephrology and Endocrinology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
Linda HilstedDepartment of Clinical Biochemistry, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
Christina ChristoffersenDepartment of Clinical Biochemistry, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
Kasper BrødbækDepartment of Clinical Biochemistry, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
Randi UgleholdtDepartment of Clinical Medicine, Faculty of Health and Medical Sciences, Copenhagen University, Copenhagen, Denmark.
Claus Larsen FeltoftDepartment of Endocrinology and Internal Medicine, Copenhagen University Hospital, Herlev, Copenhagen, Denmark.
Line Koch SkaanningDepartment of Biochemistry and Immunology, Vejle Hospital, Vejle, Denmark.
Per Medbøe ThorsbyHormone Laboratory, Dep of Medical Biochemistry and Endocrinology and Metabolism Research Group, Oslo University Hospital, Oslo, Norway.
Åse Krogh RasmussenDepartment of Nephrology and Endocrinology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
Ulla Feldt-RasmussenDepartment of Nephrology and Endocrinology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
Marianne KloseDepartment of Nephrology and Endocrinology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: Assessment of cortisol secretion in patients with adrenal incidentalomas remains challenging. We evaluated the guideline-recommended cortisol cut-off value for cortisol suppression (50 nmol/L) following a 1 mg overnight dexamethasone suppression test (DST) against a control-derived threshold and compared patient classification using the two thresholds. Secondary objectives included assessing associations of pre-DST ACTH, post-DST dexamethasone, and comorbidities with post-DST cortisol. Methods: In this cross-sectional study (NCT07350031), pre- and post-DST plasma samples from patients with adrenal incidentalomas ( Results: The 97.5 Main conclusions: The guideline-recommended post-DST cortisol threshold of 50 nmol/L may be too low, suggesting that higher thresholds warrant further evaluation.

Indexed as

Adrenal Gland NeoplasmsDexamethasoneHydrocortisoneAdrenocorticotropic HormoneAgedCase-Control StudiesCross-Sectional StudiesFemaleHumansMaleMiddle AgedProspective StudiesAdrenocorticotropic HormoneDexamethasoneHydrocortisoneadrenal incidentalomaassay performancediagnostic cut-off valuehypercortisolismmild autonomous cortisol secretionovernight dexamethasone suppression test

Identifiers

PMID42760967
PMCPMC13585637

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.