ArticleFrontiers in microbiology2026
From drug export to envelope fitness: characterizing the regulatory landscape of selective
Article in Frontiers in microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Antimicrobial resistance remains a top global health threat. While ATP-binding cassette (ABC) efflux pumps contribute to multidrug resistance in Gram-negative bacteria, their transcriptional regulation is far less understood than that of the RND and MFS families. Methods: We used DNA pull-down followed by LC-MS/MS to identify proteins binding to the promoters of five Results: Binding patterns differed sharply across the five genes. Conclusion: Our data show that ABC pumps are tightly integrated into a regulatory network governing envelope stress, osmotic adaptation, and biofilm formation-not just drug export. These findings identify candidate regulators whose putative promoter binding requires experimental validation.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.