ArticleFrontiers in medicine2026
Effect of ultrasound-guided small needle knife on patients with knee osteoarthritis: a randomized clinical trial.
Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
5 authors.
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Abstract
Background: Although ultrasound-guided small needle knife (UG-SNK) treatment combined with resistance exercise has shown benefits for knee osteoarthritis (OA) patients, evidence supporting this combination remains limited. Objective: To evaluate the efficacy and safety of combining ultrasound-guided small needle knife treatment with resistance exercise for patients with knee osteoarthritis. Methods: (1) Results: A total of 80 participants (mean [SD] age, 61.49 [10.5] years; 42 men [52.5%]) were included. At week 4, the UG-SNK-RE group showed a significant improvement in VAS scores, with a mean difference of -2.5 (-2.86 to -2.14). At week 4, the VAS score difference between the UG-SNK-RE and NSAIDs-RE groups was -1.0 (-1.40 to -0.61; Conclusion: In this randomized clinical trial, ultrasound-guided small needle knife combined with resistance exercise was more effective than NSAIDs combined with resistance exercise in improving pain, functional recovery, and muscle condition at both week 4 and week 8. These findings suggest that ultrasound-guided small needle knife treatment combined with resistance exercise is a viable alternative for managing knee osteoarthritis. Trial registration: International Traditional Medicine Clinical Trial Registry: ITMCTR2024000182.
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