Evidence map›Paper›PMID 42761557›Full record

ArticleCurrent research in neurobiology2026

Instructive signals drive learning through behavioral timescale synaptic plasticity in the hippocampus and beyond.

Lucius K Wilmerding, Fox Gourianova, Christine Grienberger

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Current research in neurobiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Lucius K WilmerdingBrandeis University, Department of Biology, Waltham, MA, 02453, USA.
Fox GourianovaBrandeis University, Department of Biology, Waltham, MA, 02453, USA.
Christine GrienbergerBrandeis University, Department of Biology, Waltham, MA, 02453, USA.

Funding

Quantitative Neuroscience: Tools for Bridging Levels of AnalysisT32NS007292 · NINDS · BRANDEIS UNIVERSITY · PI GINA G TURRIGIANO · 1986 to 2026
$12.7M
Unraveling the synaptic and circuit mechanisms underlying a plasticity-driving instructive signalDP2MH136393 · NIMH · BRANDEIS UNIVERSITY · PI Christine Grienberger · 2023 to 2026
$2.4M
CRCNS: Coordinating learning by top-down gating of plasticity in dendritesRF1MH135576 · NIMH · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · PI MILSTEIN, AARON D · 2025 to 2025
$1.2M
Undergraduate and Graduate Training in Computational Neuroscience and Data AnalysisT90DA059112 · NIDA · BRANDEIS UNIVERSITY · PI PAUL MILLER · 2023 to 2026
$873k
Dissecting the entorhinal cortex target signal for behavioral timescale synaptic plasticityF32NS143954 · NINDS · BRANDEIS UNIVERSITY · PI Lucius Kelton Wilmerding · 2025 to 2026
$154k
NIDA NIH HHS T90 DA059112NIMH NIH HHS DP2 MH136393NIMH NIH HHS RF1 MH135576NINDS NIH HHS F32 NS143954NINDS NIH HHS T32 NS007292
6 · The paper itself

Abstract

Learning requires the brain to link experience to lasting changes in neural activity, yet most experiences unfold over timescales far longer than those of classical synaptic plasticity mechanisms. Behavioral timescale synaptic plasticity (BTSP) has emerged as a candidate mechanism that bridges this gap by enabling rapid, one-shot modification of synaptic strength at the seconds timescale. BTSP is driven by dendritic Ca

Identifiers

PMID42761557
PMCPMC13587816

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.