ArticleEuropean archives of psychiatry and clinical neuroscience2026
Distinct structural abnormalities in obsessive-compulsive and alcohol use disorders.
Article in European archives of psychiatry and clinical neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Not yet cited in PubMed.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Exploration of the Potential Role of Anterior Cingulate (ACC) dTMS in Relapse to Alcohol Use
A Prospective Double Blind Randomized Controlled Trial to Evaluate the Efficacy and Durability of Accelerated BrainsWay Deep Transcranial Magnetic Stimulation (Deep TMS) Protocol in Obsessive-Compulsive Subjects
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0 citing papers in PubMed.
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Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundUnderstanding how compulsive behaviors emerge across psychiatric conditions requires mapping disorder-specific neural and potential structural mechanisms. Although Obsessive-Compulsive Disorder (OCD) and Alcohol Use Disorder (AUD) share behavioral features and involve overlapping control- and habit-learning- related circuits, these behaviors may arise from distinct circuit-level pathophysiology.
methodsHere we compared gray matter (GM) and white matter (WM) volumes across individuals with AUD, OCD, and healthy controls (HC) using a consistently acquired and uniformly processed dataset. Eighty-six non-comorbid participants (21 OCD, 9 males; 43 AUD, 27 males; and 22 HC, 14 males) underwent high-resolution T1-weighted MRI and region-based morphometry to examine group differences across 126 GM and 68 WM regions of interest.
resultsRelative to HC, the OCD and AUD groups demonstrated significant opposing patterns of GM alterations across 11 fronto-striatal, limbic, and brainstem regions, with increased volumes in OCD and decreased volumes in AUD. These volumetric differences were not correlated with severity of clinical symptoms recorded in these patients. WM analyses revealed no significant group differences.
conclusionsOur study suggests that the shared behavioral features of OCD and AUD are supported by distinct neuroanatomical mechanisms rather than a common structural substrate. Although both disorders involve overlapping circuits, the structural alterations within these networks diverge in their expression, consistent with disorder-specific pathophysiological processes. By applying region-based morphometry in a non-comorbid cohort, the present study identifies disorder-specific volumetric neural signatures in OCD and AUD, refining transdiagnostic models and underscoring the potential clinical utility of neuroimaging markers for differential diagnosis and circuit-informed intervention strategies. CLINICAL
trial registrationClinicalTrials.gov, NCT02691390 and NCT07116785.
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42762239What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.