Evidence map›Paper›PMID 42762804›Full record

ArticleJACC. Advances2026

Markers of Autonomic Function and Cancer Mortality Risk in Healthy Adults.

Clare Meernik, David Leonard, Kerem Shuval, Carolyn E Barlow, Andjelka Pavlovic, Samira Kamrudin, Lee W Jones, Kelley Pettee Gabriel, Jason R Carter, Nina Radford and 3 more

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PubMed Full text at PMC Publisher
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Article in JACC. Advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Clare MeernikKenneth H. Cooper Institute at Texas Tech University Health Sciences Center, Dallas, Texas, USA. Electronic address: clare.meernik@ttuhsc.edu.
David LeonardKenneth H. Cooper Institute at Texas Tech University Health Sciences Center, Dallas, Texas, USA.
Kerem ShuvalKenneth H. Cooper Institute at Texas Tech University Health Sciences Center, Dallas, Texas, USA.
Carolyn E BarlowKenneth H. Cooper Institute at Texas Tech University Health Sciences Center, Dallas, Texas, USA.
Andjelka PavlovicKenneth H. Cooper Institute at Texas Tech University Health Sciences Center, Dallas, Texas, USA.
Samira KamrudinJulia Jones Matthews School of Population and Public Health, Texas Tech University Health Sciences Center, Lubbock, Texas, USA.
Lee W JonesDepartment of Population Sciences, Beckman Research Institute of City of Hope, Duarte, California, USA.
Kelley Pettee GabrielDepartment of Epidemiology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Jason R CarterRobbins College of Health and Human Sciences, Baylor University, Waco, Texas, USA.
Nina RadfordCooper Clinic, Dallas, Texas, USA.
Jarett D BerryUniversity of Texas at Tyler School of Medicine, Tyler, Texas, USA.
Laura F DeFinaKenneth H. Cooper Institute at Texas Tech University Health Sciences Center, Dallas, Texas, USA.
Susan C GilchristDepartment of Medicine, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDysfunction of the autonomic nervous system increases cardiovascular risk, but its contribution to cancer outcomes is less well-characterized.

objectivesThe aim of this study was to evaluate associations between physiological measures reflective of autonomic function and all-site and site-specific cancer mortality in healthy adults.

methodsThe study included 75,308 participants (26.8% women) in the Cooper Center Longitudinal Study who completed a preventive medicine examination with a treadmill test between 1971 and 2018. Gompertz mortality models estimated associations between autonomic markers-resting heart rate, heart rate reserve, systolic blood pressure response to exercise, and heart rate recovery-and cancer mortality through 2019. Analyses were sex-stratified when significant interactions were present. Models adjusted for age, clinical and lifestyle factors, and cardiorespiratory fitness.

resultsOver a median follow-up of 21.9 years, 3,855 cancer deaths occurred. Lower heart rate reserve (HR per 10% lower: 1.05; 95% CI: 1.02-1.07) and heart rate recovery at 5 minutes (HR per 10 beats/min lower: 1.06; 95% CI: 1.03-1.09) were associated with higher all-site cancer mortality. Sex-specific associations were observed for certain markers: A higher resting heart rate was related to higher cancer mortality in men (HR per 10 beats/min: 1.04; 95% CI: 1.01-1.08), but not in women, whereas systolic blood pressure response associations were stronger in women. Associations with site-specific cancer mortality were particularly pronounced for lung cancer.

conclusionsIn apparently healthy adults, multiple noninvasive markers of autonomic function were associated with cancer mortality, independent of cardiorespiratory fitness.

Indexed as

autonomic functioncancer mortalitycardiorespiratory fitness

Identifiers

PMID42762804
PMCPMC13627117

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.