Evidence map›Paper›PMID 42763293›Full record

ArticleZhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences2026

[Protective effect of the endoplasmic reticulum stress inhibitor 4-phenylbutyric acid against myocardial injury in septic mice].

Wei Xiong, Jinwei Dai, Wenye Xu, Rui Jin, Yiting Chen, Lina Zhang, Zhaoxin Qian

Abstract readEnglish Abstract
PubMed Full text at PMC Publisher
In one paragraph

Article in Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Wei XiongDepartment of Critical Care Medicine, Xiangya Hospital, Central South University, Changsha 410008. xiongweitiantian@163.com.
Jinwei DaiDepartment of Critical Care Medicine, Xiangya Hospital, Central South University, Changsha 410008.
Wenye XuDepartment of Critical Care Medicine, Xiangya Hospital, Central South University, Changsha 410008.
Rui JinDepartment of Critical Care Medicine, Xiangya Hospital, Central South University, Changsha 410008.
Yiting ChenDepartment of Critical Care Medicine, Xiangya Hospital, Central South University, Changsha 410008.
Lina ZhangDepartment of Critical Care Medicine, Xiangya Hospital, Central South University, Changsha 410008.
Zhaoxin QianDepartment of Critical Care Medicine, Xiangya Hospital, Central South University, Changsha 410008. xyqzx@csu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesEndoplasmic reticulum stress (ERS) is an important pathophysiological mechanism involved in the development and progression of sepsis-related myocardial injury (SRMI). This study aims to investigate the protective effect of the ERS inhibitor 4‑phenylbutyric acid (4PBA) against myocardial injury in lipopolysaccharide (LPS)‑induced SRMI.

methodsAn SRMI mouse model was established by intraperitoneal injection of LPS in male C57BL/6J mice. In experiment 1, mice were randomly assigned to 5 groups (

resultsCompared with the control group, left ventricular ejection fraction (EF) and fractional shortening (FS) in the LPS 6 h, LPS 12 h, LPS 24 h, and LPS 48 h groups initially decreased and subsequently recovered over time, whereas plasma cTnI and CK-MB levels and myocardial IL-1β levels initially increased and subsequently decreased; these differences were statistically significant (all

conclusionsActivation of ERS aggravates LPS-induced SRMI, whereas 4PBA attenuates excessive ERS activation, alleviates the inflammatory response, reduces cardiomyocyte apoptosis, improves cardiac function, and decreases mortality. Targeting ERS may represent a potential therapeutic strategy for sepsis-related myocardial injury.

Indexed as

Endoplasmic Reticulum StressPhenylbutyratesSepsisAnimalsEndoplasmic Reticulum Chaperone BiPLipopolysaccharidesMaleMiceMice, Inbred C57BLMyocardium4-phenylbutyric acidEndoplasmic Reticulum Chaperone BiPHspa5 protein, mouseLipopolysaccharidesPhenylbutyrates4-phenylbutyric acidapoptosisendoplasmic reticulum stresslipopolysaccharidemyocardial injurysepsis

Identifiers

PMID42763293
PMCPMC13589773

What Socratic holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.