Evidence map›Paper›PMID 42764439›Full record

ArticleHippocampus2026

Impaired Synaptic Plasticity in a Rodent Model of Intimate Partner Violence-Related Brain Injury.

Justin Brand, Eric Eyolfson, Kirsten R B Suesser, Emma S J Smith, Zoe L Thompson, Stuart J McDonald, Jodie R Gawryluk, Sandy R Shultz, Brian R Christie

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Hippocampus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Justin BrandNeuroscience Program, School of Medical Sciences, University of Victoria, Victoria, British Columbia, Canada.ORCID https://orcid.org/0009-0005-4927-8438
Eric EyolfsonNeuroscience Program, School of Medical Sciences, University of Victoria, Victoria, British Columbia, Canada.ORCID https://orcid.org/0000-0002-2201-5444
Kirsten R B SuesserNeuroscience Program, School of Medical Sciences, University of Victoria, Victoria, British Columbia, Canada.ORCID https://orcid.org/0009-0003-7601-1988
Emma S J SmithNeuroscience Program, School of Medical Sciences, University of Victoria, Victoria, British Columbia, Canada.ORCID https://orcid.org/0009-0008-8957-9763
Zoe L ThompsonNeuroscience Program, School of Medical Sciences, University of Victoria, Victoria, British Columbia, Canada.
Stuart J McDonaldDepartment of Neuroscience, School of Translational Medicine, Monash University, Melbourne, Victoria, Australia.ORCID https://orcid.org/0000-0001-5190-3179
Jodie R GawrylukNeuroscience Program, School of Medical Sciences, University of Victoria, Victoria, British Columbia, Canada.ORCID https://orcid.org/0000-0003-4924-7517
Sandy R ShultzNeuroscience Program, School of Medical Sciences, University of Victoria, Victoria, British Columbia, Canada.ORCID https://orcid.org/0000-0002-2525-8775
Brian R ChristieNeuroscience Program, School of Medical Sciences, University of Victoria, Victoria, British Columbia, Canada.ORCID https://orcid.org/0000-0002-6830-0160

Funding

CIHR FRN 175042CIHR FRN 191316Michael Smith Health Research BC SCH-2021-188National Health and Medical Research Council GNT2010763Natural Sciences and Engineering Research Council of Canada RGPIN-2018-04829
6 · The paper itself

Abstract

Intimate partner violence-related brain injury (IPV-BI) predominantly affects women and often reflects both structural trauma from mild traumatic brain injury (mTBI), as well as ischemia/hypoxia from non-fatal strangulation (NFS). This polytrauma can impair cognitive function, particularly learning and memory processes, which may contribute to the continuation of the cycle of violence. This study investigates the effects of mTBI and hypoxic/ischemic injury on hippocampal long-term potentiation (LTP), a biological model of learning and memory, to determine if the combination of mTBI+NFS would exacerbate deficits in LTP. Female rats were randomly assigned to either Sham, mTBI, NFS, or mTBI+NFS groups to assess acute injury metrics and LTP capacity 7 days after injury. At the time of injury, NFS and mTBI+NFS groups exhibited significant reductions in blood oxygen saturation, heart rate, and poor neurological assessment metrics. Isolated mTBI and NFS impaired LTP in the CA1 hippocampal region while mTBI+NFS increased synaptic excitability in the CA1 yet impaired CA1 LTP. Contrary to our hypothesis, the combined mTBI+NFS did not exacerbate deficits, but these findings highlight that even a single episode of mTBI or NFS is sufficient to impair hippocampal LTP in the female CA1 region.

Indexed as

Brain ConcussionBrain InjuriesCA1 Region, HippocampalIntimate Partner ViolenceLong-Term PotentiationAnimalsAsphyxiaDisease Models, AnimalFemaleHippocampusRatsRats, Sprague-Dawleycornu ammonis 1hippocampuslong‐term potentiationmild traumatic brain injurynon‐fatal strangulationpolytrauma

Identifiers

PMID42764439
PMCPMC13590904

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.