Evidence map›Paper›PMID 42764615›Full record

ArticleChemistry & biodiversity2026

Thymol-Rich Lippia thymoides Mart. & Schauer (Verbenaceae) Essential Oil: Seasonal Chemical Variation, Antioxidant Capacity, Artemia salina Toxicity, and AChE Docking.

Jorddy Neves Cruz, Sebastião Gomes Silva, Angelo Antonio Barbosa Morais, Anderson Bentes de Lima, Antonio Rafael Quadros Gomes, Moises Hamoy, Eloisa Helena de Aguiar Andrade

Abstract read
In one paragraph

Article in Chemistry & biodiversity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jorddy Neves CruzAdolpho Ducke Laboratory, Botany Coordination, Emílio Goeldi Museum, Belém, Pará, Brazil.ORCID https://orcid.org/0000-0003-0529-3714
Sebastião Gomes SilvaAdolpho Ducke Laboratory, Botany Coordination, Emílio Goeldi Museum, Belém, Pará, Brazil.
Angelo Antonio Barbosa MoraisAdolpho Ducke Laboratory, Botany Coordination, Emílio Goeldi Museum, Belém, Pará, Brazil.
Anderson Bentes de LimaLaboratory of Experimental Pharmacology, State University of Pará, Belém, Pará, Brazil.ORCID https://orcid.org/0009-0003-7187-9198
Antonio Rafael Quadros GomesLaboratory of Experimental Pharmacology, State University of Pará, Belém, Pará, Brazil.
Moises HamoyLaboratory of Pharmacology and Toxicology of Natural Products, Biological Sciences Institute, Federal University of Para, Belém, Pará, Brazil.ORCID https://orcid.org/0000-0002-2931-4324
Eloisa Helena de Aguiar AndradeAdolpho Ducke Laboratory, Botany Coordination, Emílio Goeldi Museum, Belém, Pará, Brazil.ORCID https://orcid.org/0000-0003-0640-7496

Funding

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior-Brasil CAPES - 001
6 · The paper itself

Abstract

Essential oils are chemically complex natural products whose biological profiles may vary with volatile composition. This study integrated chemical characterization, antioxidant evaluation, Artemia salina lethality testing, and acetylcholinesterase (AChE) docking to investigate thymol-rich Lippia thymoides Mart. & Schauer (Verbenaceae) essential oil (LTEO) from leaves collected in September 2016 and February 2017. LTEO yield was higher in February 2017 (2.70%) than in September 2016 (2.24%). Overall, 38 constituents were identified, with thymol as the major compound in both samples (32.13% and 30.41%, respectively). The February sample showed higher proportions of monoterpene hydrocarbons, mainly p-cymene, γ-terpinene, and myrcene, whereas the September sample contained higher proportions of oxygenated monoterpenes, thymol acetate, and (E)-caryophyllene. Both samples showed radical-scavenging capacity, with numerically higher Trolox equivalent antioxidant capacity (TEAC) values for September. LTEO induced concentration-dependent lethality in A. salina, with LC

Indexed as

AcetylcholinesteraseAntioxidantsArtemiaCholinesterase InhibitorsLippiaOils, VolatileThymolAnimalsMolecular Docking SimulationPlant LeavesSeasonsAcetylcholinesteraseAntioxidantsCholinesterase InhibitorsOils, VolatileThymolacetylcholinesterasebrine shrimp lethality assaymolecular dockingradical scavenging assaysthymol

Identifiers

PMID42764615
PMCPMC13591063

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.