ArticleJournal of diabetes science and technology2026
Agreement of Over-the-Counter Continuous Glucose Monitors With Capillary-Meter Glucose in Young Adults Without Diabetes.
Article in Journal of diabetes science and technology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07255183 (Impact of Blood Glucose on Motivation States), which is not on this map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Impact of Blood Glucose on Motivation States: A Double-Blind Placebo-Controlled Study
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Authors and funding
6 authors.
Funding
Abstract
backgroundOver-the-counter continuous glucose monitors (OTC CGMs) are increasingly used by individuals without diabetes for lifestyle modification, weight management, athletics, and metabolic screening, and have potential as an affordable tool for glucose data collection in research. However, accuracy and agreement data in their intended populations are limited. No independent study has yet evaluated OTC CGM accuracy or agreement.
methodWe evaluated OTC CGMs worn by participants (n = 39) without diabetes across sessions combining rest or exercise with placebo or sugar-sweetened drink consumption that mimic scenarios in which CGM values may be used to make health-related decisions. We assessed agreement with capillary-meter glucose, interparticipant differences in CGM performance, and delay of CGM recordings.
resultsOverall mean absolute relative difference (MARD) was 12.9%, mean bias -4.8 mg/dL, and within-15%/15-mg/dL agreement 66.5%. Agreement was significantly worse under sugar than placebo consumption (MARD 15.3% vs 10.6%,
conclusionsOver-the-counter continuous glucose monitors seemingly agreed with overall capillary glucose trends but were less reliable for exact-value agreement. They may aid lifestyle monitoring but warrant caution for diagnostic thresholds, real-time change-indicator use, and research.We analyze data from a clinical trial: ClinicalTrials.gov, https://clinicaltrials.gov/study/NCT07255183?id=NCT07255183, NCT07255183. CLINICAL IMPACT: Over-the-counter continuous glucose monitors are reaching patients through primary care recommendations and direct consumer purchase, often before any structured education on interpretation. This first independent evaluation in adults without diabetes shows that OTC CGMs agree reasonably well with capillary trends but are less reliable for exact values, particularly after carbohydrate intake, at higher glucose levels, and during rapid change. Clinicians can reasonably guide patients toward using OTC CGMs to observe postprandial trends and behavioral patterns that fingerstick logs cannot practically capture, while cautioning against threshold-based decisions such as hypoglycemia detection or self-screening for diabetes, which warrant confirmatory testing.
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