ArticleAmerican journal of translational research2026
Placental pathologic score 1-2 subclinical abnormalities and early neonatal clinical indicators in term infants: a retrospective study.
Article in American journal of translational research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveTo explore the association between placental pathology scores of 1-2 and early neonatal clinical indicators, and evaluate the independent predictive effect of such abnormalities on composite adverse outcomes.
methodsThis single-center retrospective case-control study enrolled 125 term singleton live births that underwent placental pathologic examination. Based on Amsterdam Consensus scoring criteria, neonates were assigned to abnormal (score 1-2, n = 63) or control (score 0, n = 62) groups. Neonatal clinical indicators within 7 days postpartum were compared between groups, followed by multivariate logistic regression and receiver operating characteristic (ROC) curve analyses.
resultsBaseline maternal and neonatal characteristics were balanced across the two groups (all P>0.05). The abnormal group exhibited a markedly higher composite adverse outcome rate (50.8% vs. 19.4%, P<0.001), lower umbilical artery pH (7.25±0.07 vs. 7.31±0.05, P<0.001), a higher acidosis rate (19.0% vs. 0.0%, P<0.001), lower 1-h blood glucose (3.18±0.65 vs. 3.48±0.67 mmol/L, P = 0.012), and elevated C-reactive protein (CRP) levels (8.94±7.42 vs. 3.61±2.78 mg/L, P<0.001) alongside a higher proportion of CRP >10 mg/L (34.9% vs. 4.8%, P<0.001). No significant intergroup differences were observed in the incidence of clinical hypoglycemia (19.0% vs. 11.3%, P = 0.338) or intravenous antibiotic administration (3.2% vs. 4.8%, P = 0.680). Multivariate logistic regression confirmed that placental subclinical abnormalities constituted an independent risk factor for composite adverse outcome (adjusted OR = 3.779, 95% CI: 1.499-9.529, P = 0.005). The area under the ROC curve was 0.672.
conclusionsPlacental pathology scores of 1-2 are independently associated with neonatal acidosis and elevated inflammatory markers in term neonates, and correlate with a nearly fourfold increased risk of composite adverse outcome. Mild placental subclinical abnormalities should be integrated into routine neonatal risk assessment to optimize perinatal transitional care.
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