ArticleJournal of asthma and allergy2026
Dupilumab Improves Lung Function and Reduces Severe Exacerbations in Patients from China with Type 2 Asthma: A Subgroup Analysis of a Phase 3 Randomized Trial.
Article in Journal of asthma and allergy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03782532 (A Randomized, Double Blind, Placebo-controlled, Parallel-group Phase 3 Study to Evaluate the Efficacy and Safety of Dupilumab in Patients With Persistent Asthma), which is not on this map. Not yet cited in PubMed.
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A Randomized, Double Blind, Placebo-controlled, Parallel-group Phase 3 Study to Evaluate the Efficacy and Safety of Dupilumab in Patients With Persistent Asthma
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9 authors.
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Abstract
Purpose: Asthma affects approximately 46 million adults in China. The safety and efficacy of dupilumab, a monoclonal antibody which blocks the shared receptor component for interleukin (IL)-4 and IL-13, were evaluated in a phase 3 study in patients with moderate-to-severe asthma in the Asia-Pacific region (NCT03782532). This is a pre-specified subgroup analysis of patients in China derived from the Asia-Pacific trial. Patients and Methods: Patients (≥12 years) with inadequately controlled asthma despite medium/high-dose inhaled corticosteroids and ≥1 additional controller were included. Patients with type 2 inflammation (eosinophil counts ≥150 cells/µL or fractional exhaled nitric oxide ≥25 parts per billion) without maintenance oral corticosteroids (OCS) (type 2 non-OCS group, for primary efficacy analysis) were randomized 1:1 to receive 200-mg dupilumab every 2 weeks or placebo for 24 weeks. In this pre-specified subgroup analysis, primary efficacy endpoints examined included change from baseline in pre-bronchodilator forced expiratory volume in 1 second (FEV Results: In a total of 412 patients randomized from China (206 per treatment group) 347 (84.2%) were included in the primary efficacy analysis. Changes from baseline to week 12 in FEV Conclusion: In this 24-week subgroup analysis, dupilumab improved lung function, asthma control, and exacerbations, and was well tolerated in patients from China with type 2 asthma without maintenance OCS.
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