Evidence map›Paper›PMID 42765054›Full record

ArticleActa pharmaceutica Sinica. B2026

Metrnl in mitigating radiation enteritis

Sailong Zhang, Simin Chen, Bingjie Guo, Qisheng Ling, Shuling Wang, Zhuwei Miao, Zhi Wang, Yuchen Wei, Sili Zheng, Zhiyong Li and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta pharmaceutica Sinica. B, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Sailong ZhangDepartment of Pharmacology, Second Military Medical University/Naval Medical University, Shanghai 200433, China.
Simin ChenDepartment of Pharmacology, Second Military Medical University/Naval Medical University, Shanghai 200433, China.
Bingjie GuoYueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China.
Qisheng LingDepartment of Pharmacology, Second Military Medical University/Naval Medical University, Shanghai 200433, China.
Shuling WangDepartment of Gastroenterology, Changhai Hospital, Second Military Medical University/Naval Medical University, Shanghai 200433, China.
Zhuwei MiaoDepartment of Pharmacology, Second Military Medical University/Naval Medical University, Shanghai 200433, China.
Zhi WangDepartment of Pharmacology, Second Military Medical University/Naval Medical University, Shanghai 200433, China.
Yuchen WeiDepartment of Pharmacology, Second Military Medical University/Naval Medical University, Shanghai 200433, China.
Sili ZhengDepartment of Pharmacology, Second Military Medical University/Naval Medical University, Shanghai 200433, China.
Zhiyong LiDepartment of Pharmacology, Second Military Medical University/Naval Medical University, Shanghai 200433, China.
An-Qiang FengDepartment of Digestive Disease, Xuzhou Central Hospital, Xuzhou 221009, China.
Feng-Hua QianYueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China.
Chao-Yu MiaoDepartment of Pharmacology, Second Military Medical University/Naval Medical University, Shanghai 200433, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Currently, there exists no definitive standardized therapy for radiation enteritis. This study unveils Metrnl as a pivotal regulator of intestinal radioprotection through multi-dimensional single-cell profiling and mechanistic dissection. We first demonstrate that radiation dynamically reprograms Metrnl expression in a time-dependent manner, revealing its role as a radiation-responsive mediator. Crucially, Metrnl confers potent protection against radiation-induced intestinal injury through double mechanisms; Metrnl safeguards label-retaining cells (LRCs) rather than conventional Lgr5

Indexed as

c-KIT-WNT pathwayIntestinal radioprotectionIntestinal stem cellsLabel-retaining cellsMetrnlRadiation enteritisRecombinant metrnlRegenerative medicine

Identifiers

PMID42765054
PMCPMC13589954

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.