Evidence map›Paper›PMID 42765076›Full record

ArticleActa pharmaceutica Sinica. B2026

Xiangshao granules regulate the dopaminergic synapse pathway and improve menopausal anxiety in peri- and postmenopausal Chinese women: A multi-center, double-blind, randomized controlled trial.

Ruiyi Tang, Zhuolin Xie, Yubo Fan, Jing Zhang, Ling Lu, Yali Zhuang, Cunju Guo, Kuanyong Shu, Shize Li, Ping Zhang and 17 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta pharmaceutica Sinica. B, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors.

Ruiyi TangNational Clinical Research Center for Obstetric & Gynecologic Diseases, National Center for Healthcare Quality Management in Gynecological Diseases, Beijing 100730, China.
Zhuolin XieNational Clinical Research Center for Obstetric & Gynecologic Diseases, National Center for Healthcare Quality Management in Gynecological Diseases, Beijing 100730, China.
Yubo FanNational Clinical Research Center for Obstetric & Gynecologic Diseases, National Center for Healthcare Quality Management in Gynecological Diseases, Beijing 100730, China.
Jing ZhangChengdu Women's and Children's Central Hospital, Chengdu 610031, China.
Ling LuThe First Affiliated Hospital of Chengdu Medical College, Chengdu 610500, China.
Yali ZhuangAnhui Women and Children's Medical Center, Hefei 230001, China.
Cunju GuoLiaocheng People's Hospital, Liaocheng 252000, China.
Kuanyong ShuJiangxi Maternal and Child Health Hospital, Nanchang 330006, China.
Shize LiZhengzhou Central Hospital, Zhengzhou 450007, China.
Ping ZhangZhangjiagang First People's Hospital, Zhangjiagang 215600, China.
Kun LiuAffiliated Zhongshan Hospital of Dalian University, Dalian 116001, China.
Yuanyuan ZhangThe First Affiliated Hospital of Henan University, Kaifeng 475000, China.
Jianghai JiCangzhou People's Hospital, Cangzhou 061000, China.
Qingling RenJiangsu Province Hospital of Chinese Medicine, Nanjing 210029, China.
Qingfang MengTianjin Nankai Hospital, Tianjin 300100, China.
Yi LinChongqing Health Center for Women and Children, Chongqing 401147, China.
Xianghua HuangThe Second Hospital of Hebei Medical University, Shijiazhuang 050011, China.
Huimin LiGansu Province Maternity and Child Health Hospital, Lanzhou 730050, China.
Ying LiuThe Taizhou People's Hospital, Taizhou 225300, China.
Qijian DengThe Second Xiangya Hospital of Central South University, Changsha 410011, China.
Hongyan ChenBeijing ClouDNA Technology Co., Ltd., Beijing 101407, China.
Mingming SuBeijing ClouDNA Technology Co., Ltd., Beijing 101407, China.
Xinlei ZhangBeijing ClouDNA Technology Co., Ltd., Beijing 101407, China.
Yufei WangHunan Agricultural University, Changsha 410128, China.
Yaoyao LiangHunan Agricultural University, Changsha 410128, China.
Peng ZhangBeijing Key Laboratory for Genetics of Birth Defects, Beijing Pediatric Research Institute, MOE Key Laboratory of Major Diseases in Children; Rare Disease Center, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing 100045, China.
Rong ChenNational Clinical Research Center for Obstetric & Gynecologic Diseases, National Center for Healthcare Quality Management in Gynecological Diseases, Beijing 100730, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Anxiety is common among peri- and postmenopausal women, and many conventional treatments cause side effects. This multicenter, double-blind, randomized, placebo-controlled trial was conducted from December 2021 to June 2023 at 18 centers in China, enrolling 360 women aged 40‒65 years with menopausal anxiety. Participants were randomly assigned to receive Xiangshao granules (high-dose group,

Indexed as

Anxiety symptomsDopaminergic synapse pathwayMenopausal symptomsMenopauseNetwork pharmacology analysisOmicsTraditional Chinese medicineXiangshao granules

Identifiers

PMID42765076
PMCPMC13589936

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.