ArticleJID innovations : skin science from molecules to population health2026
A coordinated shift toward a macrocytic and hypochromic erythrocyte phenotype in adults with neurofibromatosis type 1.
Article in JID innovations : skin science from molecules to population health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Neurofibromatosis type 1 (NF1) is a multisystem disorder, but its hematological features remain incompletely characterized. We investigated whether erythrocyte-related indices show coordinated alterations in adults with NF1. In this retrospective single-institute study, 225 adults with NF1 were analyzed. Z-scores for erythrocyte-related parameters were calculated relative to a reference population. One-sample tests, correlation analyses, and comparisons across tumor burden (D-class) were performed. A composite score, defined as the mean of parameter-specific Z-scores, was used to assess coordinated changes. Z-scores for red blood cell count, hemoglobin, hematocrit, and mean corpuscular volume were modest but significantly increased, whereas mean corpuscular hemoglobin concentration shifted in the opposite direction. Individual effect sizes were small; however, the composite score showed a moderate effect size (Cohen's
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