Evidence map›Paper›PMID 42765288›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

Layer-Specific Dermal and Subcutaneous Delivery via Modular LNP-Hydrogel-Integrated Threaded Microneedles.

Fangzhou Xie, Yixiang Zhang, Shifeng Ling, Yuxuan Huang, Yingying Wei, Rao Fu, Jiahao He, Baikun Liu, Lucia Zhou, Kaifeng Huo and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Fangzhou Xie *Department of Plastic & Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China.
Yixiang Zhang *Department of Plastic & Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China.ORCID https://orcid.org/0000-0002-3194-3373
Shifeng Ling *Department of Orthopaedics, Shanghai Key Laboratory For Prevention and Treatment of Bone and Joint Diseases, Shanghai Institute of Traumatology and Orthopaedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China.
Yuxuan HuangDepartment of Plastic Surgery, State Key Laboratory of Trauma, Burns and Combined Injury, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, People's Republic of China.
Yingying WeiDepartment of Orthopaedics, Shanghai Key Laboratory For Prevention and Treatment of Bone and Joint Diseases, Shanghai Institute of Traumatology and Orthopaedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China.
Rao FuDepartment of Plastic & Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China.
Jiahao HeDepartment of Plastic & Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China.
Baikun LiuDepartment of Orthopaedics, Shanghai Key Laboratory For Prevention and Treatment of Bone and Joint Diseases, Shanghai Institute of Traumatology and Orthopaedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China.
Lucia ZhouDepartment of Orthopaedics, Shanghai Key Laboratory For Prevention and Treatment of Bone and Joint Diseases, Shanghai Institute of Traumatology and Orthopaedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China.ORCID https://orcid.org/0000-0001-7245-101X
Kaifeng HuoShanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China.ORCID https://orcid.org/0009-0004-7114-9643
Yida WangShanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China.
Qingfeng LiDepartment of Plastic & Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China.ORCID https://orcid.org/0000-0001-7822-618X
Yawei DuDepartment of Orthopaedics, Shanghai Key Laboratory For Prevention and Treatment of Bone and Joint Diseases, Shanghai Institute of Traumatology and Orthopaedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China.ORCID https://orcid.org/0000-0002-0829-1901
Wenguo CuiDepartment of Orthopaedics, Shanghai Key Laboratory For Prevention and Treatment of Bone and Joint Diseases, Shanghai Institute of Traumatology and Orthopaedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China.ORCID https://orcid.org/0000-0002-6938-9582
Yun XieDepartment of Plastic & Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China.ORCID https://orcid.org/0000-0002-4341-7426

Funding

National Natural Science Foundation of China 32500658National Natural Science Foundation of China 82572422National Natural Science Foundation of China 82604930Science and Technology Commission of Shanghai Municipality 22MC1940300Shanghai Clinical Research Center of Plastic and Reconstructive SurgeryThe Ruijin Hospital mRNA Drug Basic and Translational Research Project JZ202413The Shanghai Jiao Tong University School of Medicine "Clinical Full-time Research Team" Project 20250402
6 · The paper itself

Abstract

Skin diseases exhibit hierarchical pathological remodeling across the epidermis, dermis, and subcutaneous tissue. However, current therapies lack precise and controllable layer-specific intervention. Here, we present a threaded microneedle-mRNA platform enabling stratified, targeted delivery. Guided by spatial transcriptomics and clinical validation, we identified layer-specific targets in skin fibrosis. Optimized lipid nanoparticles (LNPs) were integrated into a microneedle design featuring a fast-releasing superficial hydrogel that delivers a SIRT1 agonist to mitigate dermal fibroblast senescence, and helical grooves that directionally deposit PGC1α mRNA-LNPs into subcutaneous adipose during rotational insertion for in situ expression and reversal of adipocyte fibrotic phenotypes. In bleomycin-induced murine fibrosis, the system reduced dermal senescence and ECM deposition, restored subcutaneous adipose architecture, and attenuated overall fibrosis. This layer-specific microneedle-mRNA strategy offers a precise therapeutic pathway for complex skin diseases.

Indexed as

layer‐specific deliverylipid nanoparticlesmicroneedlesmRNA therapeutics

Identifiers

PMID42765288
PMCPMC13591343

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.