ArticleHypertension (Dallas, Tex. : 1979)2026
Hypertensive Disorders of Pregnancy and Cardiovascular-Kidney-Metabolic Syndrome.
Daniel Ezzat, Maria A Pabon, Linke Li, Annie Chang, Nore De Moor, Zhi Yu, So Mi Jemma Cho, Pradeep Natarajan, Cassandra N Spracklen, Erin S LeBlanc and 13 more
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In one paragraphArticle in Hypertension (Dallas, Tex. : 1979), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
23 authors.
Daniel EzzatHeart and Vascular Institute, Mass General Brigham, Boston (D.E., M.A.P., L.L., A.C., N.D.M., Z.Y., S.M.J.C., P.N., J.D.R., R.A.H., S.M., M.C.H.).ORCID 0009-0002-6850-4275 Maria A PabonHeart and Vascular Institute, Mass General Brigham, Boston (D.E., M.A.P., L.L., A.C., N.D.M., Z.Y., S.M.J.C., P.N., J.D.R., R.A.H., S.M., M.C.H.).ORCID 0000-0003-1883-0654 Linke LiHeart and Vascular Institute, Mass General Brigham, Boston (D.E., M.A.P., L.L., A.C., N.D.M., Z.Y., S.M.J.C., P.N., J.D.R., R.A.H., S.M., M.C.H.).
Annie ChangHeart and Vascular Institute, Mass General Brigham, Boston (D.E., M.A.P., L.L., A.C., N.D.M., Z.Y., S.M.J.C., P.N., J.D.R., R.A.H., S.M., M.C.H.).
Nore De MoorHeart and Vascular Institute, Mass General Brigham, Boston (D.E., M.A.P., L.L., A.C., N.D.M., Z.Y., S.M.J.C., P.N., J.D.R., R.A.H., S.M., M.C.H.).ORCID 0009-0001-0413-4992 Zhi YuHeart and Vascular Institute, Mass General Brigham, Boston (D.E., M.A.P., L.L., A.C., N.D.M., Z.Y., S.M.J.C., P.N., J.D.R., R.A.H., S.M., M.C.H.).ORCID 0000-0003-4810-3474 So Mi Jemma ChoHeart and Vascular Institute, Mass General Brigham, Boston (D.E., M.A.P., L.L., A.C., N.D.M., Z.Y., S.M.J.C., P.N., J.D.R., R.A.H., S.M., M.C.H.).ORCID 0000-0003-2460-3335 Pradeep NatarajanHeart and Vascular Institute, Mass General Brigham, Boston (D.E., M.A.P., L.L., A.C., N.D.M., Z.Y., S.M.J.C., P.N., J.D.R., R.A.H., S.M., M.C.H.).ORCID 0000-0001-8402-7435 Cassandra N SpracklenDepartment of Biostatistics and Epidemiology, University of Massachusetts Amherst (C.N.S.).
Michael J LaMonteDepartment of Epidemiology and Environmental Health, University at Buffalo, NY (M.J.L.).ORCID 0000-0002-6669-5242 Marcia L StefanickDepartment of Medicine, Stanford Prevention Research Center, School of Medicine, Stanford University, Palo Alto, CA (M.L.S., R.A.H., S.M., O.V.D.).ORCID 0000-0002-0284-6996 JoAnn E MansonDepartment of Medicine, Harvard Medical School, Boston, MA (P.N., J.E.M., J.D.R., C.E.P., M.C.H.).ORCID 0000-0002-9426-7595 Alexander P ReinerDivision of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, WA (A.P.R.).ORCID 0000-0002-1427-4470 Jason D RohHeart and Vascular Institute, Mass General Brigham, Boston (D.E., M.A.P., L.L., A.C., N.D.M., Z.Y., S.M.J.C., P.N., J.D.R., R.A.H., S.M., M.C.H.).ORCID 0000-0002-6999-6868 Diana C Soria-ContrerasDiabetes Unit, Division of Endocrinology (D.C.S.-C., C.E.P.), Massachusetts General Hospital, Boston.ORCID 0000-0001-5783-5365 Rosangela Akemi HoshiHeart and Vascular Institute, Mass General Brigham, Boston (D.E., M.A.P., L.L., A.C., N.D.M., Z.Y., S.M.J.C., P.N., J.D.R., R.A.H., S.M., M.C.H.).ORCID 0000-0002-4034-0451 Samia MoraHeart and Vascular Institute, Mass General Brigham, Boston (D.E., M.A.P., L.L., A.C., N.D.M., Z.Y., S.M.J.C., P.N., J.D.R., R.A.H., S.M., M.C.H.).ORCID 0000-0001-6283-0980 Olga V DemlerDepartment of Medicine, Stanford Prevention Research Center, School of Medicine, Stanford University, Palo Alto, CA (M.L.S., R.A.H., S.M., O.V.D.).ORCID 0000-0003-3355-3210 Camille E PoweDepartment of Obstetrics and Gynecology (C.E.P.), Massachusetts General Hospital, Boston.ORCID 0000-0002-7060-7778 Michael C HonigbergHeart and Vascular Institute, Mass General Brigham, Boston (D.E., M.A.P., L.L., A.C., N.D.M., Z.Y., S.M.J.C., P.N., J.D.R., R.A.H., S.M., M.C.H.).ORCID 0000-0001-8630-5021 Funding
WOMEN'S HEALTH INITIATIVE - CLINICAL COORDINATING CENTER: TASK AREA B - LONG LIFE STUDY VISIT 2 LIMITED HOME VISIT75N92021D00001 · NHLBI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI ANDERSON, GARNET L. · 2021 to 2025
$52.0MWOMEN'S HEALTH INITIATIVE (WHI) REGIONAL CENTER (RC): TASK AREA A AND A275N92021D00002 · NHLBI · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI WACTAWSKI-WENDE, JEAN · 2021 to 2025
$6.9MWOMEN'S HEALTH INITIATIVE (WHI) REGIONAL CENTER (RC) - TO EXERCISE OPTION PERIOD ONE (1) AND REVISE CONTRACT ARTICLES.75N92021D00004 · NHLBI · STANFORD UNIVERSITY · PI STEFANICK, MARCIA · 2021 to 2025
$6.5MWOMEN'S HEALTH INITIATIVE (WHI) REGIONAL CENTER (RC) - TO EXERCISE OPTION PERIOD ONE (1) AND REVISE CONTRACT ARTICLES.75N92021D00003 · NHLBI · OHIO STATE UNIVERSITY · PI JACKSON, REBECCA · 2021 to 2025
$5.0MWOMEN'S HEALTH INITIATIVE (WHI) REGIONAL CENTER (RC) - TO EXERCISE OPTION PERIOD ONE (1) AND REVISE CONTRACT ARTICLES.75N92021D00005 · NHLBI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI VITOLINS, MARA · 2021 to 2025
$4.2MPlacental Senescence in Peripartum CardiomyopathyR01HL170058 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI JASON DAVID ROH · 2023 to 2026
$1.9MCardiac Effects of Mineralocorticoid Receptor Antagonism after Preeclampsia (CARDAMOM)R01HL181150 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI Michael Honigberg · 2025 to 2026
$1.3MPatient Centered Approaches to Preventing ASCVD EventsK24HL136852 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SAMIA MORA · 2018 to 2026
$1.1MIntegration of novel contextual and genomic blood pressure measures to enhance cardiovascular disease prediction and management in young adultsK99HL177340 · NHLBI · BROAD INSTITUTE, INC. · PI So Mi Cho · 2025 to 2026
$331kAmerican Heart Association-American Stroke Association 24RGRSG1275749American Heart Association-American Stroke Association 25SFRNCCKMS1443062American Heart Association-American Stroke Association 25SFRNPCKMS1463898NHLBI NIH HHS 75N92021D00001NHLBI NIH HHS 75N92021D00002NHLBI NIH HHS K24 HL136852NHLBI NIH HHS K99 HL177340NHLBI NIH HHS R01 HL170058NHLBI NIH HHS R01 HL181150WHI NIH HHS 75N92021D00003WHI NIH HHS 75N92021D00004WHI NIH HHS 75N92021D00005
6 · The paper itselfAbstract
backgroundHypertensive disorders of pregnancy (HDP) affect over 10% of pregnancies worldwide, but their association with cardiovascular-kidney-metabolic (CKM) syndrome remains unexplored.
methodsThe present study included parous UK Biobank participants. The primary exposure was HDP history. CKM syndrome was categorized from stage 0 (no risk factors) to 4 (cardiovascular disease). Logistic regression tested the association of HDP history with CKM stage, adjusted for age, age
resultsAmong 219 639 UK Biobank (mean age, 56.9 years) and 3591 Women Health Initiative participants (61.7 years at baseline, 78.1 years at the follow-up visit), 2836 (1.3%) and 304 (8.4%), respectively, had a history of HDP. In the UK Biobank, HDP history was significantly associated with higher CKM stage (adjusted odds ratio, 3.40 [95% CI, 3.12-3.71];
conclusionsHDP history was associated with greater CKM stage and progression to advanced CKM syndrome, supporting its use as an early life predictor of adverse CKM trajectories.
Indexed as
cardiovascular diseaseshypertensionkidney diseasesmetabolic diseasespregnancy
Identifiers
PMID42765319
PMCPMC13595891
What Socratic holds
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