Evidence map›Paper›PMID 42765457›Full record

ArticleExperimental dermatology2026

Selective Expansion of TCR Vβ2

Tian Y Chen, Tyler P Crowe, Maryam Fakhimi, Mia Poleksíc, Samuel H Kilgore, Patrick M Schlievert, Janet A Fairley, Kelly N Messingham

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental dermatology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Tian Y ChenDepartment of Dermatology, Carver College of Medicine, University of Iowa, Iowa, USA.ORCID https://orcid.org/0000-0003-2635-7537
Tyler P CroweDepartment of Dermatology, Carver College of Medicine, University of Iowa, Iowa, USA.ORCID https://orcid.org/0000-0002-7732-3778
Maryam FakhimiDepartment of Dermatology, Carver College of Medicine, University of Iowa, Iowa, USA.ORCID https://orcid.org/0000-0001-7475-3011
Mia PoleksícDepartment of Dermatology, Carver College of Medicine, University of Iowa, Iowa, USA.ORCID https://orcid.org/0009-0009-0639-2643
Samuel H KilgoreDepartment of Microbiology and Immunology, Carver College of Medicine, University of Iowa, Iowa, USA.ORCID https://orcid.org/0000-0002-6474-2340
Patrick M SchlievertDepartment of Microbiology and Immunology, Carver College of Medicine, University of Iowa, Iowa, USA.ORCID https://orcid.org/0000-0001-8314-9369
Janet A FairleyDepartment of Dermatology, Carver College of Medicine, University of Iowa, Iowa, USA.ORCID https://orcid.org/0000-0002-8203-0486
Kelly N MessinghamDepartment of Dermatology, Carver College of Medicine, University of Iowa, Iowa, USA.ORCID https://orcid.org/0000-0003-4630-0722

Funding

The University of Iowa Clinical and Translational Science AwardUL1TR002537 · NCATS · UNIVERSITY OF IOWA · PI HANSEN, MARLAN R, WINOKUR, PATRICIA · 2018 to 2022
$20.0M
RESEARCH TRAINING IN INFECTIOUS DISEASEST32AI007343 · NIAID · UNIVERSITY OF IOWA · PI STAPLETON, JACK T. · 1988 to 2024
$5.0M
Modulation of Cutaneous Autoimmunity by Staphylococcus AureusR21AG065980 · NIA · UNIVERSITY OF IOWA · PI FAIRLEY, JANET A, MESSINGHAM, KELLY A.N. · 2020 to 2021
$439k
NCATS NIH HHS UL1 TR002537NIAID NIH HHS T32 AI007343NIA NIH HHS R21 AG065980NIH HHS R21AG065980NIH HHS T32AI007343NIH HHS UL1TR002537Roy J. and Lucille A. Carver College of Medicine, University of IowaUniversity of IowaUniversity of Iowa Department of Dermatology
6 · The paper itself

Abstract

Bullous pemphigoid (BP) is an autoimmune blistering disease of the elderly who are frequently colonised by Staphylococcus aureus, particularly strains producing the superantigen toxic shock syndrome toxin-1 (TSST-1). Given the ability of TSST-1 to engage the T cell receptor (TCR) Vβ2 chain, we investigated whether superantigen (SAg) exposure in BP is associated with alterations in peripheral T cell populations. CD4

Indexed as

Bacterial ToxinsEnterotoxinsPemphigoid, BullousReceptors, Antigen, T-Cell, alpha-betaStaphylococcus aureusSuperantigensT-Lymphocytes, RegulatoryAgedAged, 80 and overCase-Control StudiesCD4-Positive T-LymphocytesCell ProliferationFemaleForkhead Transcription FactorsHumansMaleBacterial Toxinsenterotoxin F, StaphylococcalEnterotoxinsForkhead Transcription FactorsReceptors, Antigen, T-Cell, alpha-betaSuperantigenspemphigoid bullousStaphylococcus aureussuperantigenT‐lymphocytesTSST‐1

Identifiers

PMID42765457
PMCPMC13591492

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.