Evidence map›Paper›PMID 42766108›Full record

ArticleBasic research in cardiology2026

Short-chain fatty acids promote post-myocardial infarction cardiac repair via FFAR2-dependent suppression of osteoclast-like macrophage differentiation.

Qun Zhang, Xue Jiang, Lu Liu, Yu-Meng Jia, Pan-Pan Yu, Jie Zhang, Xin-Ying Guo, Jing-Jing Wang, Cai-Xia Guo, Lei Wang

Abstract read
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In one paragraph

Article in Basic research in cardiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Qun ZhangCardiovascular Center, Beijing Tongren Hospital, Capital Medical University, No. 1 Dongjiaomin Lane, Dongcheng District, Beijing, 100730, China.
Xue JiangCardiovascular Center, Beijing Tongren Hospital, Capital Medical University, No. 1 Dongjiaomin Lane, Dongcheng District, Beijing, 100730, China.
Lu LiuDepartment of Nutrition and Food Hygiene, Beijing Key Laboratory of Environment and Aging, School of Public Health, Capital Medical University, Beijing, 100069, China.
Yu-Meng JiaDepartment of Nutrition and Food Hygiene, Beijing Key Laboratory of Environment and Aging, School of Public Health, Capital Medical University, Beijing, 100069, China.
Pan-Pan YuCardiovascular Center, Beijing Tongren Hospital, Capital Medical University, No. 1 Dongjiaomin Lane, Dongcheng District, Beijing, 100730, China.
Jie ZhangCardiovascular Center, Beijing Tongren Hospital, Capital Medical University, No. 1 Dongjiaomin Lane, Dongcheng District, Beijing, 100730, China.
Xin-Ying GuoCardiovascular Center, Beijing Tongren Hospital, Capital Medical University, No. 1 Dongjiaomin Lane, Dongcheng District, Beijing, 100730, China.
Jing-Jing WangDepartment of Laboratory Animals, Capital Medical University, Beijing, 100069, China.
Cai-Xia Guo *Cardiovascular Center, Beijing Tongren Hospital, Capital Medical University, No. 1 Dongjiaomin Lane, Dongcheng District, Beijing, 100730, China.
Lei Wang *Department of Nutrition and Food Hygiene, Beijing Key Laboratory of Environment and Aging, School of Public Health, Capital Medical University, Beijing, 100069, China. lei.wang2@ccmu.edu.cn.ORCID http://orcid.org/0009-0005-0050-0691

Funding

Beijing High-Level Public Health Technical Talent Program-Leading Talent Leading Talent-03-02Beijing Natural Science Foundation 7232022Capital's Funds for Health Improvement and Research 2024-1-2051National Natural Science Foundation of China 82171808National Natural Science Foundation of China 82200369National Natural Science Foundation of China 82370263Noncommunicable Chronic Diseases-National Science and Technology Major Project No.2024ZD0531200priming scientific research foundation for the junior researcher in Beijing Tongren Hospital, Capital Medical University 2021-YJJ-ZZL-001priming scientific research foundation for the junior researcher in Beijing Tongren Hospital, Capital Medical University 2022-YJJ-ZZL-015
6 · The paper itself

Abstract

Adverse cardiac remodeling leads to the development of heart failure following myocardial infarction (MI), yet the immunometabolic signals governing early infarct repair remain poorly understood. Short-chain fatty acids (SCFAs) are important immunometabolic regulators, but their relevance and mechanistic contribution to post-MI repair remain unclear. Here, we integrated clinical observations with genetic and pharmacological intervention studies to investigate the role of the SCFAs-free fatty acid receptor 2 (FFAR2) axis in post-MI repair. Circulating SCFAs levels were markedly decreased in patients with MI, and associated with more complex coronary lesions and a higher risk of major adverse cardiovascular events. In murine MI, SCFAs supplementation reduced infarct expansion, cardiomyocyte death, and cardiac rupture, and improved left-ventricular function. These benefits were lost in global and myeloid-specific Ffar2-deficient mice, demonstrating an essential role for myeloid FFAR2 in SCFA-mediated cardioprotection. Mechanistically, SCFAs activated FFAR2-G

Indexed as

Adverse cardiac remodelingFree fatty acid receptor 2Myocardial infarctionOsteoclast-like macrophageShort-chain fatty acids

Identifiers

PMID42766108

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.