Evidence map›Paper›PMID 42766124›Full record

ArticleClinical research in cardiology : official journal of the German Cardiac Society2026

Associations of CMR-based pulse wave velocity and aortic distensibility with infrarenal ultrasound-based aortic parameters in the Hamburg City Health Study.

Katharina Alina Riedl, Eleonora Di Carluccio, Gunnar Lund, Markus Huellebrand, Anja Hennemuth, Rickmer Braren, Paulus Kirchhof, Stefan Blankenberg, Lisa Tilemann, Andreas Ziegler and 3 more

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Article in Clinical research in cardiology : official journal of the German Cardiac Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

13 authors.

Katharina Alina RiedlDepartment of Cardiology, University Heart and Vascular Center Hamburg, University Medical Center Hamburg, Martinistraße 52, 20246, Hamburg, Germany. k.riedl@uke.de.ORCID http://orcid.org/0000-0001-5956-0051
Eleonora Di CarluccioCardio-CARE, Medizincampus Davos, Davos, Switzerland.
Gunnar LundDepartment of Radiology and Nuclear Medicine, University Medical Center Hamburg, Hamburg, Germany.
Markus HuellebrandDeutsches Herzzentrum der Charité (DHZC), Berlin, Germany.
Anja HennemuthDepartment of Radiology and Nuclear Medicine, University Medical Center Hamburg, Hamburg, Germany.
Rickmer BrarenDepartment of Radiology and Nuclear Medicine, University Medical Center Hamburg, Hamburg, Germany.
Paulus KirchhofDepartment of Cardiology, University Heart and Vascular Center Hamburg, University Medical Center Hamburg, Martinistraße 52, 20246, Hamburg, Germany.
Stefan BlankenbergDepartment of Cardiology, University Heart and Vascular Center Hamburg, University Medical Center Hamburg, Martinistraße 52, 20246, Hamburg, Germany.
Lisa TilemannDepartment of Vascular Medicine, University Heart and Vascular Center Hamburg, University Medical Center Hamburg, Hamburg, Germany.
Andreas ZieglerDepartment of Cardiology, University Heart and Vascular Center Hamburg, University Medical Center Hamburg, Martinistraße 52, 20246, Hamburg, Germany.
Christian- Alexander BehrendtDepartment of Vascular and Endovascular Surgery, Asklepios Clinic Wandsbek, Hamburg, Germany.
Kai MuellerleileDepartment of Cardiology, University Heart and Vascular Center Hamburg, University Medical Center Hamburg, Martinistraße 52, 20246, Hamburg, Germany.
Tilo KölbelDepartment of Vascular Medicine, University Heart and Vascular Center Hamburg, University Medical Center Hamburg, Hamburg, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAlthough pulse wave velocity (PWV) and aortic distensibility (AD) can be readily obtained from cardiac magnetic resonance imaging (CMR), there is a paucity of data on their use for screening for abdominal aortic aneurysm (AAA) and cardiovascular risk stratification.

methodsData from the Hamburg City Health Study (HCHS) were used: PWV, AD of the ascending (AD AoAsc) and descending aorta (AD AoDesc) were quantified using 2D-phase-contrast-velocity-encoding-CMR-sequences. The maximum diameter and peak flow velocity of the infrarenal aorta were quantified by ultrasound-measurements. Diameter thresholds for infrarenal ectasia (25-29 mm) and aneurysm (≥ 30 mm) were defined in accordance with current guidelines.

resultsThe cohort consisted of 2,093 participants (median age 66 years, 42% women). Median infrarenal aortic diameter was 18.1 mm [IQR 16.4, 19.9] and peak flow velocity 98.6 cm/s [IQR 83.6,115.9]. After adjustment for age and sex, there were significant associations of diameter with AD AoDesc (Coefficient -0.572 p = 0.009) and of peak flow velocity with PWV (Coefficient -0.399, p = 0.029). Participants with infrarenal ectasia or aneurysm (n = 55) had significantly higher median PWV, whereas AD AoAsc, AD AoDesc and peak flow velocity were significantly lower (p = 0.004, p = 0.042, p = 0.039, p < 0.001) compared with normal aortic diameter cohort. After adjustment for covariates, PWV and AD showed a significant predictive value neither for prevalent infrarenal ectasia or nor for aneurysm.

conclusionCMR-based aortic stiffness parameters such as PWV and AD were associated with infrarenal aortic parameters. Their diagnostic, screening, and prognostic value remains to be investigated.

Indexed as

Abdominal aortic aneurysmAortic distensibilityAortic stiffnessCMRInfrarenal aortic aneurysmPulse wave velocity

Identifiers

PMID42766124

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.