ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2026
Post mortem MRI of cholinergic white matter pathways across neurodegenerative diseases.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
introductionCholinergic white matter pathway (CWMP) degeneration is central in Alzheimer's disease (AD) and Lewy body disease (LBD). CWMP degeneration can be assessed in vivo using magnetic resonance imaging (MRI) proxies, but neuropathological validation is limited.
methodsWe studied post mortem in situ 3T MRIs of 55 brain donors with standardized neuropathologic assessment (AD, LBD, AD+LBD, other dementias, controls). CWMP integrity was assessed quantitatively using diffusion tensor imaging and visually using the Cholinergic Pathways Hyperintensities Scale (CHIPS) on fluid-attenuated inversion recovery MRI.
resultsCWMP diffusivity was strongly associated with CHIPS (p < 0.001), independent of global white matter damage. AD and AD+LBD showed greater CWMP degeneration than LBD, other dementias, and controls (p < 0.05). Multivariate analyses across neuropathological variables identified hippocampal sclerosis and vascular co-pathology as strongest predictors for CWMP degeneration. DISCUSSION: CWMP degeneration is pronounced in AD and mixed AD+LBD pathology and is additionally affected by vascular co-pathology and hippocampal sclerosis. CHIPS may serve as a clinically accessible MRI-based proxy of CWMP integrity.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.