Evidence map›Paper›PMID 42768111›Full record

ArticleNature aging2026

RamanOmics decodes the spatial vibrational-molecular architecture of senescence in aging and repair.

Ke Zhang, Xingjian Chen, Francesco Monticolo, Salvatore Sorrentino, Haochun Huang, Claire Callahan, Yueqing Qiao, Judy Zhou, Sonia Brodowska, Styliani Sapantzi and 15 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature aging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Ke Zhang *Cutaneous Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-6153-6912
Xingjian Chen *Cutaneous Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0001-9639-1584
Francesco Monticolo *Cutaneous Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Salvatore Sorrentino *Cutaneous Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0001-9125-5225
Haochun HuangCutaneous Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Claire CallahanCutaneous Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Yueqing QiaoCutaneous Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Judy ZhouCutaneous Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Sonia BrodowskaCutaneous Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Styliani SapantziCutaneous Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Jianhuan QiCutaneous Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Yinghan WuCutaneous Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Thai Nam Son DangCutaneous Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Yanwan CaoCutaneous Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Sumin KangCutaneous Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0009-0000-7595-2979
Francesca ViggianiCutaneous Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Chia-Kang HoKrantz Family Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0002-6861-7870
Yanxin XuKrantz Family Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA.
Koseki J Kobayashi-KirschvinkLaser Biomedical Research Center, G. R. Harrison Spectroscopy Laboratory, Massachusetts Institute of Technology, Cambridge, MA, USA.ORCID http://orcid.org/0000-0001-6590-3823
Thang MungCutaneous Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Hemali PhatnaniCenter for Genomics of Neurodegenerative Disease, New York Genome Center, New York, NY, USA.
Zhixun DouKrantz Family Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0002-3069-3907
Jeon Woong KangLaser Biomedical Research Center, G. R. Harrison Spectroscopy Laboratory, Massachusetts Institute of Technology, Cambridge, MA, USA. jwkang76@mit.edu.ORCID http://orcid.org/0000-0003-2012-9023
Peter T C SoLaser Biomedical Research Center, G. R. Harrison Spectroscopy Laboratory, Massachusetts Institute of Technology, Cambridge, MA, USA. ptso@mit.edu.ORCID http://orcid.org/0000-0003-4698-6488
Jian ShuCutaneous Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. jian.shu@mgh.harvard.edu.ORCID http://orcid.org/0000-0001-9390-9333

Funding

Data Analysis CoreU54AG076040 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MENON, VILAS · 2021 to 2025
$13.1M
U.S. Department of Health & Human Services | National Institutes of Health (NIH) U54AG076040U.S. Department of Health & Human Services | National Institutes of Health (NIH) UG3CA268117, UH3CA268117U.S. Department of Health & Human Services | National Institutes of Health (NIH) UG3CA275687, UH3CA275687, 1DP2AG080320-01U.S. Department of Health & Human Services | National Institutes of Health (NIH) UG3CA275687, UH3CA275687, P41EB015871U.S. Department of Health & Human Services | National Institutes of Health (NIH) UG3CA275687, UH3CA275687, P41EB015871, R01DC021326
6 · The paper itself

Abstract

Aging and tissue repair involve heterogeneous remodeling across transcriptional, biochemical and cellular dimensions, yet prevailing definitions rely on isolated molecular markers that obscure how these states co-evolve. Here we present RamanOmics, a multimodal framework integrating label-free hyperspectral Raman imaging with single-nucleus RNA sequencing and spatial transcriptomics to link biochemical states with transcriptional programs at single-cell spatial resolution. Applied to young and old mouse lung and skin, RamanOmics reveals tissue-specific programs: lung senescent cells are enriched for extracellular matrix remodeling and transforming growth factor-β signaling, whereas skin senescence is dominated by epidermal differentiation genes (Krt10, Lor and Sbsn). Across tissues, we identified a conserved lipid-linked Raman signature (1,131-1,135 cm

Identifiers

PMID42768111

What Socratic holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.