Evidence map›Paper›PMID 42768223›Full record

ArticleNature immunology2026

Deletion of a distal IRF4 element prevents inflammation-induced reprogramming of human regulatory T cell fate.

Patrick Ho, Alexander Vu, Joey Leung, Wendy Rosenthal, Vasilis Ntranos, Jeffrey A Bluestone, Qizhi Tang

Abstract read
In one paragraph

Article in Nature immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Patrick Ho *Diabetes Center, University of California, San Francisco, San Francisco, CA, USA. ho_p@ukw.de.ORCID http://orcid.org/0000-0003-4751-6904
Alexander Vu *Diabetes Center, University of California, San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0003-0597-7518
Joey LeungDiabetes Center, University of California, San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-2528-9555
Wendy RosenthalDiabetes Center, University of California, San Francisco, San Francisco, CA, USA.
Vasilis NtranosDiabetes Center, University of California, San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-2477-0670
Jeffrey A BluestoneDiabetes Center, University of California, San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0001-8793-7848
Qizhi TangDiabetes Center, University of California, San Francisco, San Francisco, CA, USA. qizhi.tang@ucsf.edu.ORCID http://orcid.org/0000-0001-7313-3574

Funding

MOLECULAR AND CELLULAR IMMUNOLOGYT32AI007334 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CYSTER, JASON G · 1988 to 2023
$11.0M
UCSF Type 1 Diabetes Research CenterP30DK135103 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Julie Beth Sneddon · 2025 to 2026
$5.1M
Designer Tregs for restoring tolerance in patients with type 1 diabetesUC4DK116264 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BLUESTONE, JEFFREY A, LIM, WENDELL A · 2017 to 2017
$3.4M
Division of Intramural Research, National Institute of Allergy and Infectious Diseases (Division of Intramural Research of the NIAID) UC4 DK116264Leona M. and Harry B. Helmsley Charitable Trust (Helmsley Charitable Trust) G-2109-04813National Science Foundation (NSF) 2445150NIAID NIH HHS T32 AI007334NIDDK NIH HHS P30 DK135103NIDDK NIH HHS UC4 DK116264U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID) T32 5T32AI007334-35U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (National Institute of Diabetes & Digestive & Kidney Diseases) P30DK135103-01U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (National Institute of Diabetes & Digestive & Kidney Diseases) UC4 DK116264
6 · The paper itself

Abstract

Regulatory T (T

Indexed as

Cellular ReprogrammingInflammationInterferon Regulatory FactorsT-Lymphocytes, RegulatoryAnimalsCell DifferentiationCell LineageCytokinesForkhead Transcription FactorsHumansInterferon Regulatory Factor-4MiceTranscription Factor AP-1CytokinesForkhead Transcription FactorsFOXP3 protein, humanInterferon Regulatory Factor-4Interferon Regulatory FactorsTranscription Factor AP-1

Identifiers

PMID42768223
PMCPMC13630568

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.