Evidence map›Paper›PMID 42769056›Full record

ArticleFrontiers in oncology2026

Fibroblast-derived gremlin-1 Is associated with ovarian cancer-cell phenotypes in co-culture models.

Haocheng Gao, Mengjuan Xia, Ting Yu, Xiaofang Chen, Xiaojuan Li, Heqiu Ruan

Abstract read
In one paragraph

Article in Frontiers in oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Haocheng GaoDepartment of Gynecology, Hainan General Hospital/Hainan Medical University Hainan Hospital, Haikou, Hainan, China.
Mengjuan XiaMedical Laboratory Center, Hainan General Hospital/Hainan Medical University Hainan Hospital, Haikou, Hainan, China.
Ting YuDepartment of Pharmacy, Hainan General Hospital/Hainan Medical University Hainan Hospital, Haikou, Hainan, China.
Xiaofang ChenBiomedical Statistics Office, Hainan General Hospital/Hainan Medical University Hainan Hospital, Haikou, Hainan, China.
Xiaojuan LiMedical Laboratory Center, Hainan General Hospital/Hainan Medical University Hainan Hospital, Haikou, Hainan, China.
Heqiu RuanMedical Laboratory Center, Hainan General Hospital/Hainan Medical University Hainan Hospital, Haikou, Hainan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Cancer-associated fibroblasts (CAFs) can modify ovarian cancer-cell behavior through paracrine signals, but the contribution of CAF-derived Gremlin-1 remains incompletely defined. Methods: We compared stage IV and stage I ovarian-cancer transcriptomes in GSE9891, performed functional-enrichment analyses of differentially expressed genes, and interrogated CSIOVDB and KM Plotter for Results: GSE9891 DEGs were enriched in ECM-related processes. CSIOVDB associated higher Conclusion: CAF

Indexed as

cancer-associated fibroblastsepithelial-mesenchymal TransitionFGFR1/MEK/ERKgrem1ovarian cancertumor microenvironment

Identifiers

PMID42769056
PMCPMC13590338

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.