Evidence map›Paper›PMID 42769060›Full record

ArticleFrontiers in endocrinology2026

Premature ovarian insufficiency in patients with thyroid-related poly-autoimmunity.

Maria Flavia Bagaglini, Ilaria Stramazzo, Matteo Nocito, Poupak Fallahi, Alessandro Antonelli, Maria Giulia Santaguida, Lucilla Gargano, Francesca Ferrari, Enke Baldini, Salvatore Ulisse and 3 more

Abstract read
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In one paragraph

Article in Frontiers in endocrinology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Maria Flavia BagagliniDepartment of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Rome, Italy.
Ilaria StramazzoDepartment of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Rome, Italy.
Matteo NocitoDepartment of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Rome, Italy.
Poupak FallahiDepartment of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy.
Alessandro AntonelliDepartment of Surgical, Medical and Molecular Pathology and Critical Area, University of Pisa, Pisa, Italy.
Maria Giulia SantaguidaAzienda Sanitaria Locale (ASL) Latina, Latina, Italy.
Lucilla GarganoAzienda Sanitaria Locale (ASL) Latina, Latina, Italy.
Francesca FerrariDepartment of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Rome, Italy.
Enke BaldiniDepartment of Surgery, Sapienza University of Rome, Rome, Italy.
Salvatore UlisseDepartment of Surgery, Sapienza University of Rome, Rome, Italy.
Anna CarrettiDepartment of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Rome, Italy.
Marco CentanniDepartment of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Rome, Italy.
Camilla ViriliDepartment of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: An anticipated menopause is a disquieting health problem; its association with autoimmune disorders has been reported. However, data about the presence of premature ovarian insufficiency (POI) and early menopause (EM) framed in thyroid-related poly-autoimmunity are rather scanty. In this view, we described the presence of a precocious menopause in a large cohort of women with autoimmune thyroid disease (ATD) isolated or framed in poly-autoimmune syndromes. Study design: The characteristics of 7,690 postmenopausal women has been evaluated in a tertiary center for thyroid diseases. To be included, women must have been menopausal for at least 3 years without any menstrual bleeding. Three subgroups were examined and compared: women with nonautoimmune endocrinopathies ( Results: In the whole sample, 213 (2.77%) women experienced unexplained precocious menopause, 115 (1.50%) showed spontaneous premature ovarian insufficiency (POI), and 98 (1.27%) experienced early menopause (EM). The prevalence of POI was higher in women with thyroid-related poly-autoimmunity (group C) than in group B and A (5.92 vs. 1.84 vs. 1.16%; Conclusions: Our data strongly suggest that young women with thyroid-related poly-autoimmunity, born to a family with thyroid-related poly-autoimmunity, should have their ovarian reserve checked early to guide fertility preservation and family planning.

Indexed as

Menopause, PrematurePrimary Ovarian InsufficiencyThyroiditis, AutoimmuneAdultFemaleHumansMiddle AgedPrevalenceHashimoto’s thyroiditismiscarriagepoly-autoimmunitypremature ovarian failurepremature ovarian insufficiency

Identifiers

PMID42769060
PMCPMC13590396

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.