ArticleInternational journal of women's health2026
Peripheral Blood Transcriptomic Features Distinguishing Postpartum Depression from Major Depressive Disorder and Healthy Postpartum Controls.
Article in International journal of women's health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Purpose: Postpartum depression (PPD) is a common mental disorder, yet its pathogenesis remains incompletely understood. This study compared peripheral blood mononuclear cell (PBMC) transcriptomes across three cohorts-PPD, major depressive disorder (MDD), and healthy postpartum control (HPC)-to elucidate the molecular mechanisms underlying PPD and identify features that distinguish it from non-postpartum depression. Patients and Methods: A total of 47 participants were recruited, including 11 with PPD, 16 HPC, and 20 with MDD. PBMCs were collected for transcriptome sequencing. Differentially expressed genes (DEGs) were identified using thresholds of |log2FC| ≥ 1 and Results: Given that multiple testing correction identified only a limited number of DEGs, DEG analysis in this study was performed as an exploratory analysis using unadjusted Conclusion: The findings suggest peripheral transcriptomic alterations involving changes in humoral immunity, reduced
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