ArticleFrontiers in medicine2026
Joint blood pressure and resting heart rate trajectories and net adverse clinical events risk following PCI: an inverse probability of treatment weighting analysis.
Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Evidence is limited on the prospective prognostic value of longitudinal blood pressure (BP) and resting heart rate (RHR) dynamics after percutaneous coronary intervention (PCI). Aim: This study aimed to identify joint BP-RHR trajectories and evaluate their impact on net adverse clinical events (NACE). Methods: In a prospective post-PCI cohort, latent class trajectory modeling identified 6-month patterns of systolic BP, diastolic BP, and RHR, classifying patients into four joint trajectories. Inverse probability of treatment weighting (IPTW) was employed to rigorously balance baseline confounders. The primary endpoint was NACE. The incremental predictive value of the joint trajectories was assessed using the C-index, continuous net reclassification improvement (cNRI), and integrated discrimination improvement (IDI). Results: Among 736 patients (71 NACE events during follow-up), four distinct joint trajectory groups were identified: Double Stable ( Conclusion: Joint BP and RHR trajectories effectively stratify post-PCI NACE risk. Patients with combined fluctuations face the highest risk, highlighting the need for dynamic hemodynamic monitoring over static single-point assessments.
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