Evidence map›Paper›PMID 42769163›Full record

ArticleFrontiers in immunology2026

PLA2G2F/lysoplasmalogen axis links epidermal lipid metabolism to type 2 inflammation and itch in atopic dermatitis.

Yoshimi Miki, Natsumi Higashisaka, Honami Inubushi, Niki Hirabayashi, Kanji Watanabe, Saho Fukui, Masayoshi Onitsuka, Chiaki Fukaura, Mariko Ogawa-Momohara, Kana Tanahashi and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Yoshimi Miki *Division of Bioscience and Bioindustry, Graduate School of Technology, Industrial and Social Sciences, Tokushima University, Tokushima, Japan.
Natsumi HigashisakaDivision of Bioscience and Bioindustry, Graduate School of Technology, Industrial and Social Sciences, Tokushima University, Tokushima, Japan.
Honami InubushiDivision of Bioscience and Bioindustry, Graduate School of Technology, Industrial and Social Sciences, Tokushima University, Tokushima, Japan.
Niki HirabayashiDivision of Bioscience and Bioindustry, Graduate School of Technology, Industrial and Social Sciences, Tokushima University, Tokushima, Japan.
Kanji WatanabeDivision of Bioscience and Bioindustry, Graduate School of Technology, Industrial and Social Sciences, Tokushima University, Tokushima, Japan.
Saho FukuiDivision of Bioscience and Bioindustry, Graduate School of Technology, Industrial and Social Sciences, Tokushima University, Tokushima, Japan.
Masayoshi OnitsukaDivision of Bioscience and Bioindustry, Graduate School of Technology, Industrial and Social Sciences, Tokushima University, Tokushima, Japan.
Chiaki FukauraDepartment of Dermatology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Mariko Ogawa-MomoharaDepartment of Dermatology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Kana TanahashiDepartment of Dermatology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Yuki NagasakiLaboratory of Microenvironmental Metabolic Health Sciences, Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Takuya TakeichiDepartment of Dermatology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Masashi AkiyamaDepartment of Dermatology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Makoto MurakamiLaboratory of Microenvironmental Metabolic Health Sciences, Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Kei Yamamoto *Division of Bioscience and Bioindustry, Graduate School of Technology, Industrial and Social Sciences, Tokushima University, Tokushima, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Atopic dermatitis is a chronic inflammatory skin disease characterized by type 2 immune responses and severe itching; however, the molecular mechanisms linking lipid metabolism to epithelial-immune signaling remain incompletely understood. Herein, we show that group IIF secreted phospholipase A

Indexed as

Dermatitis, AtopicEpidermisGroup II Phospholipases A2Lipid MetabolismLysophospholipidsPlasmalogensPruritusAnimalsDisease Models, AnimalFemaleHumansInflammationInterleukin-33KeratinocytesMaleMiceGroup II Phospholipases A2Interleukin-33lysophosphatidylethanolamineLysophospholipidsPlasmalogensatopic dermatitisitchlipidomicslysoplasmalogenphospholipase A2

Identifiers

PMID42769163
PMCPMC13590317

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.