Trial reportFrontiers in immunology2026
Changes in circulating immune cells and cytokines after high-intensity aerobic exercise in patients with prostate cancer undergoing active surveillance from the ERASE randomized controlled trial.
Trial report in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Exercise can modulate immune function and inflammatory signaling in cancer populations; however, its effects on the immune system in men with localized prostate cancer undergoing active surveillance are unknown. This study examined the effects of high-intensity interval training (HIIT) on circulating immune cell phenotypes, function, and systemic cytokine levels in this clinical setting. Methods: This was a secondary analysis of the Exercise During Active Surveillance for Prostate Cancer (ERASE) trial, a single-center randomized controlled trial. Fifty-two men with localized prostate cancer on active surveillance were randomized to a 12-week supervised aerobic HIIT program (n=26) or usual care (n=26). HIIT consisted of three sessions per week at 85% to 95% of peak oxygen consumption. Fasting blood samples were collected at baseline and post-intervention. Changes in immune cell subsets (T cells, B cells, and NK cells; flow cytometry), NK cell cytotoxicity, and plasma cytokine concentrations were assessed. Analyses of covariance were used to compare between-group differences. Results: The HIIT group attended 96% of prescribed sessions. Compared with usual care, the HIIT group showed a significant increase in the proportion of the circulating major NK-cell subset (CD3-CD56+CD16+) (adjusted between-group difference, 2.0%; 95% CI, 0.3 to 3.7; p=0.024) and PBMC-mediated cytotoxicity against K562 (2.9%; 95% CI, 0.3 to 5.4; p=0.031). A significant between-group decrease was also observed in basophil counts (-0.04 ×10 Conclusions: A 12-week supervised HIIT program significantly increased the proportion of the circulating major NK-cell subset and PBMC-mediated cytotoxicity while reducing IL-4 and IL-12p70 concentrations in men with prostate cancer undergoing active surveillance. Because these were peripheral-blood measures rather than tumor-level readouts, and given the exploratory design and number of comparisons, these findings should be interpreted as hypothesis-generating and require confirmation in larger, adequately powered studies.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.