Evidence map›Paper›PMID 42769320›Full record

ArticleAmerican journal of translational research2026

Novel histone deacetylase 6 gene variant is associated with fetal hydrocephalus and lateral ventriculomegaly.

Xuliang Zhao, Qiang Ji, Xu Li, Feng Chen, Ying Jiang, Ruixia Tian

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Article in American journal of translational research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Xuliang ZhaoDepartment of Laboratory, Chizhou Maternal and Child Health Care Hospital Chizhou, Anhui, China.
Qiang JiChizhou Birth Defects Management Office Chizhou, Anhui, China.
Xu LiDepartment of Radiology, Anhui Children's Hospital Hefei, Anhui, China.
Feng ChenDepartment of Obstetrics and Gynecology, The 901th Hospital of The Joint Service of The People's Liberation Army Hefei, Anhui, China.
Ying JiangDepartment of Ultrasound, The Third People's Hospital of Chizhou Chizhou, Anhui, China.
Ruixia TianDepartment of Obstetrics and Gynecology, The 901th Hospital of The Joint Service of The People's Liberation Army Hefei, Anhui, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesCongenital hydrocephalus (CH) is a neurological disease that significantly impacts fetal nervous system development and subsequent quality of life. CH pathogenesis may be linked to genetic factors such as defects in the histone deacetylase 6 (

methodsSkin tissue from a fetal-induced abortion as well as peripheral blood samples from both parents were collected for analysis. Whole-exome and Sanger sequencing were used to analyze fetal germline variants, and variant plasmids were constructed for western blot (WB) experiments; cycloheximide (CHX) chase assays with or without MG132 were further performed to assess protein degradation kinetics.

resultsIn the fetal tissue, a variant of the

conclusionsThe frameshift variant in the

Indexed as

congenital hydrocephalusHDAC6histone deacetylase 6ventriculomegaly

Identifiers

PMID42769320
PMCPMC13590692

What Socratic holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.