ArticleFrontiers in endocrinology2026
Ultrasound-guided radiofrequency ablation versus laparoscopic adrenalectomy for unilateral isolated aldosterone-producing adenoma: a two-center retrospective study.
Article in Frontiers in endocrinology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: This study aimed to evaluate the safety and efficacy of Ultrasound-guided radiofrequency ablation (US-guided RFA) compared to laparoscopic adrenalectomy (LA) for the treatment of aldosterone-producing adenoma (APA). Methods: This retrospective, two-center study evaluated 100 patients with APA treated with either US-guided RFA or LA between January 2020 and June 2024. Patients were categorized based on treatment modality (US-guided RFA: n=36; LA: n=64). To minimize confounding, a 1:1 matching was performed based on sex, age, medical history, and disease characteristics. Post-treatment outcomes, including biochemical remission and blood pressure control, were compared using independent-samples t-tests or chi-square tests. Results: A total of 36 patients (median age: 49.5 years [IQR: 33.25-57.00]; 23 women) underwent US-guided RFA, and 36 matched patients (median age: 52.00 years [IQR: 37.50-59.75]; 20 women) underwent LA. The technical success rate was 100% in both groups. During the follow-up period (median: 14 months [IQR: 6-22 months]), both groups achieved complete biochemical remission (36/36, Conclusion: In patients with unilateral isolated APA, no significant differences were observed between US-guided RFA and LA in terms of disease progression, biochemical remission, or hypertension control in the short term.
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