ArticleFASEB bioAdvances2026
Methodological Pitfalls in Endometriosis Biospecimen Research: Lessons From MAP4K4 Expression Studies.
Article in FASEB bioAdvances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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8 authors.
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Abstract
Endometriosis is a chronic inflammatory condition affecting 10% of reproductive-age women. Current treatments remain limited and non-curative. While its biology is largely informed by human biospecimens, sample heterogeneity and methodological constraints often limit interpretability. Using mitogen-activated protein kinase 4 (MAP4K4), a cell motility and invasion regulator within the MAPK network, as a model molecule, we examined its expression in endometriosis to highlight challenges in biospecimen-based research. Public endometrial microarray datasets were re-analyzed using a standard limma pipeline to evaluate
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