Evidence map›Paper›PMID 42769728›Full record

ReviewFrontiers in cardiovascular medicine2026

Aberrant myocardial calcium cycling: pathogenic mechanisms and targeted therapeutics for heart failure.

Chunxiao Zhao, Jiahao Liu, Juanjuan Xin, Qun Liu, Ying Zhang, Xiaochun Yu, Junhong Gao

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in cardiovascular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Chunxiao Zhao *The Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, Shandong, China.
Jiahao Liu *Jinan Municipal Government Hospital, Jinan, Shandong, China.
Juanjuan XinInstitute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing, China.
Qun LiuInstitute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing, China.
Ying ZhangInstitute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing, China.
Xiaochun YuInstitute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing, China.
Junhong GaoInstitute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cardiovascular diseases rank as the global primary cause of mortality. Heart failure (HF) represents a progressive cardiac syndrome triggered by structural or functional myocardial damage that compromises ventricular systolic output. Intracellular calcium homeostasis underpins cardiomyocyte excitation-contraction coupling. Calcium overload and dysregulated calcium handling act as central pathogenic forces driving HF progression. Sympathetic β

Indexed as

autonomic neural regulationcalcium cyclingcalcium cycling-related proteinsexcitation-contraction couplingheart failure

Identifiers

PMID42769728
PMCPMC13591147

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.