ArticleFrontiers in microbiology2026
CUMS alters behavioral phenotypes and gut mycobiota in mice.
Article in Frontiers in microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: To investigate the effects of chronic unpredictable mild stress (CUMS) on the gut fungal community in mice and its association with anxiety-like behaviors. Methods: C57BL/6 male mice were randomly divided into a control group and a CUMS group, with 10 mice per group. The CUMS group was exposed to a 3-week regimen of chronic stressors (damp bedding, food and water deprivation, continuous light exposure, tail pinch, cage tilting, restraint, and forced swimming). Anxiety-like behaviors were assessed using the elevated plus maze (EPM) and open field test (OFT). Colonic contents were collected for ITS high-throughput sequencing. Alterations in the gut fungal community and their correlations with behavioral parameters were evaluated through α-diversity and β-diversity analyses, LEfSe differential analysis, Spearman correlation analysis and co-occurrence network analysis. Results: Compared with the control group, the CUMS group showed significantly reduced percentage of open-arm entries and percentage of time spent in open arms in the EPM ( Conclusion: This study firstly demonstrates that chronic unpredictable mild stress (CUMS) induces profound ecological remodeling of the gut fungal community, characterized by the enrichment of
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