Evidence map›Paper›PMID 42769975›Full record

ReviewFrontiers in immunology2026

IL-10's contextual role in cytotoxic antitumor immunity: evidence, controversies, and therapeutic translation.

Minchuan Zhang, Qi-Jing Li, Kong Peng Lam, Shengli Xu

Abstract readReview
In one paragraph

Review in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Minchuan ZhangSingapore Immunology Network, Agency for Science, Technology, and Research, Singapore, Singapore.
Qi-Jing LiInstitute of Molecular and Cell Biology, Agency for Science, Technology, and Research, Singapore, Singapore.
Kong Peng LamSingapore Immunology Network, Agency for Science, Technology, and Research, Singapore, Singapore.
Shengli XuSingapore Immunology Network, Agency for Science, Technology, and Research, Singapore, Singapore.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Interleukin-10 (IL-10) is classically defined as a potent anti-inflammatory cytokine that protects tissues by constraining myeloid activation and limiting inflammatory cytokine production. Yet, accumulating evidence indicates that, in defined contexts, IL-10 can also promote antitumor immunity by enhancing the fitness and cytotoxic programs of CD8

Indexed as

Cytotoxicity, ImmunologicInterleukin-10NeoplasmsAnimalsHumansKiller Cells, NaturalSignal TransductionT-Lymphocytes, CytotoxicTranslational Research, BiomedicalTumor MicroenvironmentInterleukin-10cancer immunotherapyCAR-T cellCD8+ T cellsIL-10 receptor blockadeinterleukin-10metabolic reprogrammingnatural killer cellsT-cell exhaustion

Identifiers

PMID42769975
PMCPMC13591624

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.